Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094157466> ?p ?o ?g. }
- W3094157466 endingPage "3073" @default.
- W3094157466 startingPage "3073" @default.
- W3094157466 abstract "Genetic dynamics underlying cancer progression are largely unknown and several genes involved in highly prevalent illnesses (e.g., hypertension, obesity, and diabetes) strongly concur to cancer phenotype heterogeneity. To study genotype-phenotype relationships contributing to the mutational evolution of colorectal cancer (CRC) with a focus on liver metastases, we performed genome profiling on tumor tissues of CRC patients with liver metastatic disease and no co-morbidities. We studied 523 cancer-related genes and tumor-immune microenvironment characteristics in primary and matched metastatic tissues. We observed a loss of KRAS and SMAD4 alterations and a high granzyme-B+ T-cell infiltration when the disease did not progress. Conversely, gain in KRAS, PIK3CA and SMAD4 alterations and scarce granzyme-B+ T-cells infiltration were observed when the tumor evolved towards a poly-metastatic spread. These findings provide novel insights into the identification of tumor oligo-metastatic status, indicating that some genes are on a boundary line between these two clinical settings (oligo- vs. poly-metastatic CRC). We speculate that the identification of these genes and modification of their evolution could be a new approach for anti-cancer therapeutic strategies." @default.
- W3094157466 created "2020-10-29" @default.
- W3094157466 creator A5005784207 @default.
- W3094157466 creator A5005851993 @default.
- W3094157466 creator A5006827360 @default.
- W3094157466 creator A5010247390 @default.
- W3094157466 creator A5015577953 @default.
- W3094157466 creator A5016966886 @default.
- W3094157466 creator A5018880335 @default.
- W3094157466 creator A5027147759 @default.
- W3094157466 creator A5028542645 @default.
- W3094157466 creator A5035669120 @default.
- W3094157466 creator A5040277868 @default.
- W3094157466 creator A5042758138 @default.
- W3094157466 creator A5052216253 @default.
- W3094157466 creator A5056681575 @default.
- W3094157466 creator A5070615133 @default.
- W3094157466 creator A5071949598 @default.
- W3094157466 creator A5073891277 @default.
- W3094157466 creator A5074752423 @default.
- W3094157466 creator A5080064151 @default.
- W3094157466 creator A5091003529 @default.
- W3094157466 date "2020-10-21" @default.
- W3094157466 modified "2023-10-05" @default.
- W3094157466 title "Evolution of Mutational Landscape and Tumor Immune-Microenvironment in Liver Oligo-Metastatic Colorectal Cancer" @default.
- W3094157466 cites W1976287566 @default.
- W3094157466 cites W1997785236 @default.
- W3094157466 cites W2004959159 @default.
- W3094157466 cites W2033052459 @default.
- W3094157466 cites W2035746711 @default.
- W3094157466 cites W2046783953 @default.
- W3094157466 cites W2070140741 @default.
- W3094157466 cites W2075230059 @default.
- W3094157466 cites W2083456650 @default.
- W3094157466 cites W2085416202 @default.
- W3094157466 cites W2086351006 @default.
- W3094157466 cites W2103441770 @default.
- W3094157466 cites W2119763874 @default.
- W3094157466 cites W2151021868 @default.
- W3094157466 cites W2166459387 @default.
- W3094157466 cites W2173807505 @default.
- W3094157466 cites W2262414037 @default.
- W3094157466 cites W2395807466 @default.
- W3094157466 cites W2401276597 @default.
- W3094157466 cites W2474217759 @default.
- W3094157466 cites W2509157748 @default.
- W3094157466 cites W2566723262 @default.
- W3094157466 cites W2586177716 @default.
- W3094157466 cites W2602781230 @default.
- W3094157466 cites W2606495925 @default.
- W3094157466 cites W2609904336 @default.
- W3094157466 cites W2611153539 @default.
- W3094157466 cites W2766425839 @default.
- W3094157466 cites W2768873001 @default.
- W3094157466 cites W2780090036 @default.
- W3094157466 cites W2788842984 @default.
- W3094157466 cites W2790580076 @default.
- W3094157466 cites W2802206159 @default.
- W3094157466 cites W2802626256 @default.
- W3094157466 cites W2810475801 @default.
- W3094157466 cites W2895926103 @default.
- W3094157466 cites W2899802902 @default.
- W3094157466 cites W2953390364 @default.
- W3094157466 cites W2963433753 @default.
- W3094157466 cites W2965294890 @default.
- W3094157466 cites W2975035173 @default.
- W3094157466 cites W2976346750 @default.
- W3094157466 cites W2980009698 @default.
- W3094157466 cites W2985533020 @default.
- W3094157466 cites W2989663721 @default.
- W3094157466 cites W2996981493 @default.
- W3094157466 cites W3019815717 @default.
- W3094157466 cites W3031471547 @default.
- W3094157466 cites W4240340450 @default.
- W3094157466 cites W954754213 @default.
- W3094157466 doi "https://doi.org/10.3390/cancers12103073" @default.
- W3094157466 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7589866" @default.
- W3094157466 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33096795" @default.
- W3094157466 hasPublicationYear "2020" @default.
- W3094157466 type Work @default.
- W3094157466 sameAs 3094157466 @default.
- W3094157466 citedByCount "21" @default.
- W3094157466 countsByYear W30941574662021 @default.
- W3094157466 countsByYear W30941574662022 @default.
- W3094157466 countsByYear W30941574662023 @default.
- W3094157466 crossrefType "journal-article" @default.
- W3094157466 hasAuthorship W3094157466A5005784207 @default.
- W3094157466 hasAuthorship W3094157466A5005851993 @default.
- W3094157466 hasAuthorship W3094157466A5006827360 @default.
- W3094157466 hasAuthorship W3094157466A5010247390 @default.
- W3094157466 hasAuthorship W3094157466A5015577953 @default.
- W3094157466 hasAuthorship W3094157466A5016966886 @default.
- W3094157466 hasAuthorship W3094157466A5018880335 @default.
- W3094157466 hasAuthorship W3094157466A5027147759 @default.
- W3094157466 hasAuthorship W3094157466A5028542645 @default.
- W3094157466 hasAuthorship W3094157466A5035669120 @default.
- W3094157466 hasAuthorship W3094157466A5040277868 @default.
- W3094157466 hasAuthorship W3094157466A5042758138 @default.