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- W3094164554 abstract "Abstract Hippocampal volume is an important biomarker of Alzheimer’s disease (AD), and genetic risk of AD is associated with hippocampal atrophy. However, the hippocampus is not a uniform structure and has a number of subfields, the associations of which with age, sex, and polygenic risk score for AD (PRS AD ) have been inadequately investigated. We examined these associations in 17,161 cognitively normal UK Biobank participants (44-80 years). Age was negatively associated with all the hippocampal subfield volumes and females had smaller volumes than men. Higher PRS AD was associated with lower volumes in the bilateral whole hippocampus, hippocampal-amygdala-transition-area (HATA), and hippocampal tail; right subiculum; left cornu ammonis (CA)1, CA4, molecular layer, and granule cell layer of dentate gyrus (CG-DG), with associations being greater on the left side. Older individuals (median age 63 years, n=8984) showed greater subfield vulnerability to high PRS AD compared to the younger group (n=8177), but the effect did not differ by sex. The pattern of subfield involvement in relation to the PRS AD in community dwelling healthy individuals sheds additional light on the pathogenesis of AD." @default.
- W3094164554 created "2020-10-29" @default.
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- W3094164554 date "2020-10-27" @default.
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- W3094164554 title "Associations between Alzheimer’s disease polygenic risk scores and hippocampal subfield volumes in 17,161 UK Biobank participants" @default.
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- W3094164554 doi "https://doi.org/10.1101/2020.10.24.20218925" @default.
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