Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094174927> ?p ?o ?g. }
- W3094174927 endingPage "1075" @default.
- W3094174927 startingPage "1063" @default.
- W3094174927 abstract "Abstract Aminoglycoside antibiotics are widely used for many life‐threatening infections. The use of aminoglycosides is often comprised by their deleterious side effects to the kidney and inner ear. A novel semisynthetic antibiotic, etimicin, has good antimicrobial activity against both gram‐positive and gram‐negative bacteria. But its toxicity profile analysis is still lacking. In the present study, we compared the in vivo toxic effects of three aminoglycosides, gentamicin, amikacin, and etimicin, in zebrafish embryos. We examined the embryotoxicity, nephrotoxicity, and the damage to the neuromast hair cells. Our results revealed that etimicin and amikacin exhibit more developmental toxicities to the young embryos than gentamicin. But at subtoxic doses, etimicin and amikacin show significantly reduced toxicities towards kidney and neuromast hair cells. We further demonstrated that fluorescently conjugated aminoglycosides (gentamicin‐Texas red [GTTR], amikacin‐Texas red [AMTR], and etimicin‐Texas red [ETTR]) all enter the hair cells properly. Inside the hair cells, gentamicin, not etimicin and amikacin, displays robust reactive oxygen species generation and induces apoptosis. Our data support that the different intracellular cytotoxicity underlies the different ototoxicity of the three aminoglycosides and that etimicin is a new aminoglycoside with reduced risk of nephrotoxicity and ototoxicity." @default.
- W3094174927 created "2020-10-29" @default.
- W3094174927 creator A5011639911 @default.
- W3094174927 creator A5027184139 @default.
- W3094174927 creator A5031819155 @default.
- W3094174927 creator A5043620679 @default.
- W3094174927 creator A5052793972 @default.
- W3094174927 creator A5065888580 @default.
- W3094174927 creator A5074335599 @default.
- W3094174927 creator A5078069217 @default.
- W3094174927 creator A5081127855 @default.
- W3094174927 date "2020-10-22" @default.
- W3094174927 modified "2023-10-04" @default.
- W3094174927 title "A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos" @default.
- W3094174927 cites W1493367564 @default.
- W3094174927 cites W1963506121 @default.
- W3094174927 cites W1965850555 @default.
- W3094174927 cites W1966542503 @default.
- W3094174927 cites W1969878671 @default.
- W3094174927 cites W1974820129 @default.
- W3094174927 cites W1977690514 @default.
- W3094174927 cites W1982119955 @default.
- W3094174927 cites W1982915980 @default.
- W3094174927 cites W2000515001 @default.
- W3094174927 cites W2007551053 @default.
- W3094174927 cites W2014208948 @default.
- W3094174927 cites W2033184553 @default.
- W3094174927 cites W2036470338 @default.
- W3094174927 cites W2040252262 @default.
- W3094174927 cites W2040895520 @default.
- W3094174927 cites W2041592951 @default.
- W3094174927 cites W2043351945 @default.
- W3094174927 cites W2044613056 @default.
- W3094174927 cites W2051014369 @default.
- W3094174927 cites W2057995143 @default.
- W3094174927 cites W2061041662 @default.
- W3094174927 cites W2063902684 @default.
- W3094174927 cites W2066976865 @default.
- W3094174927 cites W2072316722 @default.
- W3094174927 cites W2074742688 @default.
- W3094174927 cites W2083329120 @default.
- W3094174927 cites W2085992814 @default.
- W3094174927 cites W2086487301 @default.
- W3094174927 cites W2091508032 @default.
- W3094174927 cites W2123541991 @default.
- W3094174927 cites W2125349610 @default.
- W3094174927 cites W2131227793 @default.
- W3094174927 cites W2142750959 @default.
- W3094174927 cites W2298339347 @default.
- W3094174927 cites W2416290591 @default.
- W3094174927 cites W2461883491 @default.
- W3094174927 cites W2483712829 @default.
- W3094174927 cites W2519819581 @default.
- W3094174927 cites W2594701775 @default.
- W3094174927 cites W2735030163 @default.
- W3094174927 cites W2761759723 @default.
- W3094174927 cites W2766221660 @default.
- W3094174927 cites W2778638554 @default.
- W3094174927 cites W2791253432 @default.
- W3094174927 cites W2791394169 @default.
- W3094174927 cites W2890956175 @default.
- W3094174927 cites W2900417385 @default.
- W3094174927 doi "https://doi.org/10.1002/jat.4093" @default.
- W3094174927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33094525" @default.
- W3094174927 hasPublicationYear "2020" @default.
- W3094174927 type Work @default.
- W3094174927 sameAs 3094174927 @default.
- W3094174927 citedByCount "9" @default.
- W3094174927 countsByYear W30941749272021 @default.
- W3094174927 countsByYear W30941749272022 @default.
- W3094174927 countsByYear W30941749272023 @default.
- W3094174927 crossrefType "journal-article" @default.
- W3094174927 hasAuthorship W3094174927A5011639911 @default.
- W3094174927 hasAuthorship W3094174927A5027184139 @default.
- W3094174927 hasAuthorship W3094174927A5031819155 @default.
- W3094174927 hasAuthorship W3094174927A5043620679 @default.
- W3094174927 hasAuthorship W3094174927A5052793972 @default.
- W3094174927 hasAuthorship W3094174927A5065888580 @default.
- W3094174927 hasAuthorship W3094174927A5074335599 @default.
- W3094174927 hasAuthorship W3094174927A5078069217 @default.
- W3094174927 hasAuthorship W3094174927A5081127855 @default.
- W3094174927 hasConcept C105702510 @default.
- W3094174927 hasConcept C126189478 @default.
- W3094174927 hasConcept C126322002 @default.
- W3094174927 hasConcept C2775832221 @default.
- W3094174927 hasConcept C2776694085 @default.
- W3094174927 hasConcept C2777427914 @default.
- W3094174927 hasConcept C2777787772 @default.
- W3094174927 hasConcept C2778239845 @default.
- W3094174927 hasConcept C2778534666 @default.
- W3094174927 hasConcept C2778585322 @default.
- W3094174927 hasConcept C2780130748 @default.
- W3094174927 hasConcept C29730261 @default.
- W3094174927 hasConcept C501593827 @default.
- W3094174927 hasConcept C71924100 @default.
- W3094174927 hasConcept C86803240 @default.
- W3094174927 hasConcept C89423630 @default.
- W3094174927 hasConcept C98274493 @default.