Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094179699> ?p ?o ?g. }
- W3094179699 endingPage "192" @default.
- W3094179699 startingPage "182" @default.
- W3094179699 abstract "Abstract Background: Overexpression of the receptor for advanced glycation end-product (RAGE) has been associated with chronic inflammation, which in turn has been associated with increased colorectal cancer risk. Soluble RAGE (sRAGE) competes with RAGE to bind its ligands, thus potentially preventing RAGE-induced inflammation. Methods: To investigate whether sRAGE and related genetic variants are associated with colorectal cancer risk, we conducted a nested case–control study in the European Prospective Investigation into Cancer and Nutrition (EPIC). Plasma sRAGE concentrations were measured by ELISA in 1,361 colorectal cancer matched case–control sets. Twenty-four SNPs encoded in the genes associated with sRAGE concentrations were available for 1,985 colorectal cancer cases and 2,220 controls. Multivariable adjusted ORs and 95% confidence intervals (CIs) were computed using conditional and unconditional logistic regression for colorectal cancer risk and circulating sRAGE and SNPs, respectively. Results: Higher sRAGE concentrations were inversely associated with colorectal cancer (ORQ5vs.Q1, 0.77; 95% CI, 0.59–1.00). Sex-specific analyses revealed that the observed inverse risk association was restricted to men (ORQ5vs.Q1, 0.63; 95% CI, 0.42–0.94), whereas no association was observed in women (ORQ5vs.Q1, 1.00; 95% CI, 0.68–1.48; Pheterogeneity for sex = 0.006). Participants carrying minor allele of rs653765 (promoter region of ADAM10) had lower colorectal cancer risk (C vs. T, OR, 0.90; 95% CI, 0.82–0.99). Conclusions: Prediagnostic sRAGE concentrations were inversely associated with colorectal cancer risk in men, but not in women. An SNP located within ADAM10 gene, pertaining to RAGE shedding, was associated with colorectal cancer risk. Impact: Further studies are needed to confirm our observed sex difference in the association and better explore the potential involvement of genetic variants of sRAGE in colorectal cancer development." @default.
- W3094179699 created "2020-10-29" @default.
- W3094179699 creator A5000739842 @default.
- W3094179699 creator A5009955420 @default.
- W3094179699 creator A5010043187 @default.
- W3094179699 creator A5014315256 @default.
- W3094179699 creator A5017818032 @default.
- W3094179699 creator A5018086802 @default.
- W3094179699 creator A5023472770 @default.
- W3094179699 creator A5025874788 @default.
- W3094179699 creator A5031265369 @default.
- W3094179699 creator A5031874687 @default.
- W3094179699 creator A5035488801 @default.
- W3094179699 creator A5036547753 @default.
- W3094179699 creator A5038151302 @default.
- W3094179699 creator A5039013705 @default.
- W3094179699 creator A5040664403 @default.
- W3094179699 creator A5043080647 @default.
- W3094179699 creator A5048179797 @default.
- W3094179699 creator A5054532454 @default.
- W3094179699 creator A5056390607 @default.
- W3094179699 creator A5058149593 @default.
- W3094179699 creator A5058232300 @default.
- W3094179699 creator A5058638270 @default.
- W3094179699 creator A5059406911 @default.
- W3094179699 creator A5061360756 @default.
- W3094179699 creator A5065704442 @default.
- W3094179699 creator A5067228080 @default.
- W3094179699 creator A5067980710 @default.
- W3094179699 creator A5068376010 @default.
- W3094179699 creator A5071426386 @default.
- W3094179699 creator A5071536718 @default.
- W3094179699 creator A5073106549 @default.
- W3094179699 creator A5074815814 @default.
- W3094179699 creator A5079099154 @default.
- W3094179699 creator A5082652255 @default.
- W3094179699 creator A5083367439 @default.
- W3094179699 creator A5083450375 @default.
- W3094179699 creator A5084605060 @default.
- W3094179699 creator A5084786313 @default.
- W3094179699 creator A5084986158 @default.
- W3094179699 creator A5085715708 @default.
- W3094179699 creator A5086826772 @default.
- W3094179699 creator A5086839304 @default.
- W3094179699 creator A5088761090 @default.
- W3094179699 creator A5089462484 @default.
- W3094179699 creator A5090492717 @default.
- W3094179699 date "2021-01-01" @default.
- W3094179699 modified "2023-10-17" @default.
- W3094179699 title "Soluble Receptor for Advanced Glycation End-products (sRAGE) and Colorectal Cancer Risk: A Case–Control Study Nested within a European Prospective Cohort" @default.
- W3094179699 cites W1965609542 @default.
- W3094179699 cites W1967172372 @default.
- W3094179699 cites W1967680475 @default.
- W3094179699 cites W1979248549 @default.
- W3094179699 cites W1982509489 @default.
- W3094179699 cites W1984854708 @default.
- W3094179699 cites W1985775184 @default.
- W3094179699 cites W1987603842 @default.
- W3094179699 cites W1990324489 @default.
- W3094179699 cites W1990748107 @default.
- W3094179699 cites W2011187443 @default.
- W3094179699 cites W2013463636 @default.
- W3094179699 cites W2019396341 @default.
- W3094179699 cites W2019567863 @default.
- W3094179699 cites W2039184577 @default.
- W3094179699 cites W2045442917 @default.
- W3094179699 cites W2069435653 @default.
- W3094179699 cites W2075093885 @default.
- W3094179699 cites W2076752066 @default.
- W3094179699 cites W2081080245 @default.
- W3094179699 cites W2083301109 @default.
- W3094179699 cites W2084898158 @default.
- W3094179699 cites W2086327676 @default.
- W3094179699 cites W2100383922 @default.
- W3094179699 cites W2110569461 @default.
- W3094179699 cites W2116794323 @default.
- W3094179699 cites W2121323998 @default.
- W3094179699 cites W2127620487 @default.
- W3094179699 cites W2139355636 @default.
- W3094179699 cites W2148399674 @default.
- W3094179699 cites W2150107415 @default.
- W3094179699 cites W2157043395 @default.
- W3094179699 cites W2164970501 @default.
- W3094179699 cites W2222113396 @default.
- W3094179699 cites W2255567964 @default.
- W3094179699 cites W2276493358 @default.
- W3094179699 cites W2291025194 @default.
- W3094179699 cites W2340833841 @default.
- W3094179699 cites W2519455161 @default.
- W3094179699 cites W2572954835 @default.
- W3094179699 cites W2587192173 @default.
- W3094179699 cites W2588613084 @default.
- W3094179699 cites W2788736028 @default.
- W3094179699 cites W2793564034 @default.
- W3094179699 cites W2805040489 @default.
- W3094179699 cites W2885753783 @default.
- W3094179699 cites W2888450730 @default.
- W3094179699 cites W2901478735 @default.