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- W3094199365 abstract "Cadmium (Cd) is an occupational and environmental pollutant, which mainly causes nephrotoxicity by damaging renal proximal tubular cells. To evaluate the effects of Cd on pyroptosis and the relationship between pyroptosis and apoptosis in duck renal tubular epithelial cells, the cells were cultured with 3CdSO4·8H2O (0, 2.5, 5.0, or 10.0 μM Cd), N-acetyl-L-cysteine (NAC) (100.0 μM), Z-YVAD-FMK (10.0 μM) or the combination of Cd and NAC or Z-YVAD-FMK for 12 h, and then cytotoxicity was assessed. The results evidenced that Cd significantly increased the releases of interleukin-18 (IL-18) and interleukin-1β (IL-1β), lactate dehydrogenase (LDH) and nitric oxide (NO), relative conductivity and cellular reactive oxygen species (ROS) level. Simultaneously, Cd also markedly upregulated NLRP3, Caspase-1, ASC, NEK7, IL-1β and IL-18 mRNA levels and NLRP3, Caspase-1 p20, GSDMD and ASC protein levels. Additionally, NAC notably improved the changes of above indicators induced by Cd. Combined treatment with Cd and Z-YVAD-FMK remarkably elevated Bcl-2 mRNA and protein levels, inhibited p53, Bax, Bak-1, Cyt C, Caspase-9 and Caspase-3 mRNA levels and p53, Bax, Bak-1, Caspase-9/cleaved Caspase-9 and Caspase-3/cleaved Caspase-3 protein levels, increased mitochondrial membrane potential (MMP), decreased apoptosis ratio and cell damage compared to treatment with Cd alone. Taken together, Cd exposure induces duck renal tubular epithelial cell pyroptosis through ROS/NLRP3/Caspase-1 signaling pathway, and inhibiting Caspase-1 dependent pyroptosis attenuates Cd-induced apoptosis." @default.
- W3094199365 created "2020-10-29" @default.
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- W3094199365 date "2021-03-01" @default.
- W3094199365 modified "2023-10-01" @default.
- W3094199365 title "Inhibition of ROS/NLRP3/Caspase-1 mediated pyroptosis attenuates cadmium-induced apoptosis in duck renal tubular epithelial cells" @default.
- W3094199365 cites W1491753771 @default.
- W3094199365 cites W1864325817 @default.
- W3094199365 cites W1882905539 @default.
- W3094199365 cites W1968022114 @default.
- W3094199365 cites W1969491440 @default.
- W3094199365 cites W1972403225 @default.
- W3094199365 cites W1974340416 @default.
- W3094199365 cites W1976150153 @default.
- W3094199365 cites W1984174923 @default.
- W3094199365 cites W1985970823 @default.
- W3094199365 cites W2003351572 @default.
- W3094199365 cites W2004263066 @default.
- W3094199365 cites W2006403463 @default.
- W3094199365 cites W2016599845 @default.
- W3094199365 cites W2037382204 @default.
- W3094199365 cites W2048171730 @default.
- W3094199365 cites W2048243484 @default.
- W3094199365 cites W2048385139 @default.
- W3094199365 cites W2050449334 @default.
- W3094199365 cites W2056325589 @default.
- W3094199365 cites W2060258231 @default.
- W3094199365 cites W2060871468 @default.
- W3094199365 cites W2064513411 @default.
- W3094199365 cites W2064890121 @default.
- W3094199365 cites W2075611712 @default.
- W3094199365 cites W2081297751 @default.
- W3094199365 cites W2088741444 @default.
- W3094199365 cites W2089503694 @default.
- W3094199365 cites W2132242647 @default.
- W3094199365 cites W2154613843 @default.
- W3094199365 cites W2174549829 @default.
- W3094199365 cites W2201316930 @default.
- W3094199365 cites W2237547158 @default.
- W3094199365 cites W2254807163 @default.
- W3094199365 cites W2257734931 @default.
- W3094199365 cites W2335332173 @default.
- W3094199365 cites W2408954743 @default.
- W3094199365 cites W2464242197 @default.
- W3094199365 cites W2507586450 @default.
- W3094199365 cites W2560541542 @default.
- W3094199365 cites W2564122215 @default.
- W3094199365 cites W2565671276 @default.
- W3094199365 cites W2588695514 @default.
- W3094199365 cites W2592209809 @default.
- W3094199365 cites W2604323436 @default.
- W3094199365 cites W2605111984 @default.
- W3094199365 cites W2608687752 @default.
- W3094199365 cites W2736447551 @default.
- W3094199365 cites W2756985996 @default.
- W3094199365 cites W2762112545 @default.
- W3094199365 cites W2775436800 @default.
- W3094199365 cites W2789997601 @default.
- W3094199365 cites W2790634443 @default.
- W3094199365 cites W2790797952 @default.
- W3094199365 cites W2794644642 @default.
- W3094199365 cites W2799435656 @default.
- W3094199365 cites W2801710926 @default.
- W3094199365 cites W2886601273 @default.
- W3094199365 cites W2890600421 @default.
- W3094199365 cites W2896399648 @default.
- W3094199365 cites W2917742147 @default.
- W3094199365 cites W2936926067 @default.
- W3094199365 cites W2942035615 @default.
- W3094199365 cites W2944457167 @default.
- W3094199365 cites W2952863642 @default.
- W3094199365 cites W2955768268 @default.
- W3094199365 cites W2963752638 @default.
- W3094199365 cites W2964546283 @default.
- W3094199365 cites W2971649607 @default.
- W3094199365 cites W2979662825 @default.
- W3094199365 cites W2980560502 @default.
- W3094199365 cites W2999638502 @default.
- W3094199365 cites W3023145028 @default.
- W3094199365 cites W3033976925 @default.
- W3094199365 cites W3035101438 @default.
- W3094199365 cites W3035382912 @default.
- W3094199365 doi "https://doi.org/10.1016/j.envpol.2020.115919" @default.
- W3094199365 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33497945" @default.
- W3094199365 hasPublicationYear "2021" @default.
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