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- W3094216308 abstract "Gemcitabine is a well known anticancer drug which can be used to treat a broad series of hard tumors as well as pancreatic, breast, ovarian and lung cancers. It is converted to (2′, 2′-difluorodeoxyuridine) an inactive derivative by cytidine deaminase enzyme inside the body. Due to fast metabolism by enzyme and rapid excretion by kidney its efficiency reduces. So to increase the efficiency it is advised to take high doses of gemcitabine which results in gastrointestinal toxicity. In addition to this a lot of cancers develop resistance for gemcitabine. To improve, its cytotoxic activity, metabolic stability and to reduce the mechanism of drug delivery technologies are needed to deal with these shortcomings many new methods have been developed, such as the creation of prodrugs. A prodrug is a biologically inactive form of a main drug that usually within the body needs a chemical transformation in order to liberate the drug, and has enhanced the release of drug as compared to the original molecule [1]. This review summarizes the chemical modifications of gemcitabine. They can give a defence against the removal of amino group, a prolonged release in the cell and a better storage. These innovative gemcitabine based systems have the possibility to increase the effectiveness of gemcitabine." @default.
- W3094216308 created "2020-10-29" @default.
- W3094216308 creator A5025811477 @default.
- W3094216308 date "2021-01-01" @default.
- W3094216308 modified "2023-09-26" @default.
- W3094216308 title "A review on gemcitabine modification" @default.
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- W3094216308 doi "https://doi.org/10.1016/j.matpr.2020.09.118" @default.
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