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• W3094265721 abstract "Extracts of Peperomia pellucida [L.] Kunth have previously been demonstrated to have in vivo estrogenic-like effects, thereby functioning as an anti-osteoporotic agent. However, the compounds responsible for these effects have not yet been determined. Therefore, the aim of this study is to isolate and elucidate potential compounds with estrogenic activity. The structures of the isolated compounds were identified using 1D 1H and 13C-NMR and confirmed by 2D FT-NMR. The estrogenic activity was evaluated using the E-SCREEN assay, and a molecular docking study was performed to predict the binding affinity of the isolated compounds to estrogen receptors. In this experiment, we successfully isolated three phenylpropanoids and two lignan derivatives, namely, 6-allyl-5-methoxy-1,3-benzodioxol-4-ol (1), pachypostaudin B (2), pellucidin A (3), dillapiole (4), and apiol (5). Among these compounds, the isolation of 1 and 2 from P. pellucida is reported for the first time in this study. Activity assays clearly showed that the ethyl acetate extract and its fractions, subfractions, and isolated compounds exerted estrogenic activity. Methanol fraction of the ethyl acetate extract produced the highest estrogenic activity, while 1 and 2 had partial agonist activity. Some compounds (derivates of dillapiole and pellucidin A) also had, in addition, anti-estrogenic activity. In the docking study, the estrogenic activities of 1–5 appeared to be mediated by a classical ligand-dependent mechanism as suggested by the binding interaction between the compounds and estrogen receptors; binding occurred on Arg 394 and His 524 of the alpha receptor and Arg 346 and His 475 of the beta receptor. In summary, we reveal that P. pellucida is a promising anti-osteoporotic agent due to its estrogenic activity, and the compounds responsible for this activity were found to be lignan and phenylpropanoid derivatives. The presence of other compounds in either the extract or fraction may contribute to a synergistic effect, as suggested by the higher estrogenic activity of the methanol fraction. Hence, we suggest further research on the osteoporotic activity and safety of the identified compounds, especially regarding their effects on estrogen-responsive organs." @default.
• W3094265721 created "2020-10-29" @default.
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• W3094265721 date "2020-10-23" @default.
• W3094265721 modified "2023-09-27" @default.
• W3094265721 title "Isolation and Characterization of Phenylpropanoid and Lignan Compounds from Peperomia pellucida [L.] Kunth with Estrogenic Activities" @default.
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• W3094265721 cites W1571431043 @default.
• W3094265721 cites W1963592407 @default.
• W3094265721 cites W1965290126 @default.
• W3094265721 cites W1966272418 @default.
• W3094265721 cites W1968599011 @default.
• W3094265721 cites W1970869473 @default.
• W3094265721 cites W1976482107 @default.
• W3094265721 cites W1979858258 @default.
• W3094265721 cites W2000142411 @default.
• W3094265721 cites W2000524802 @default.
• W3094265721 cites W2005550563 @default.
• W3094265721 cites W2006067715 @default.
• W3094265721 cites W2007433764 @default.
• W3094265721 cites W2008425069 @default.
• W3094265721 cites W2020258087 @default.
• W3094265721 cites W2024173696 @default.
• W3094265721 cites W2024737359 @default.
• W3094265721 cites W2024905084 @default.
• W3094265721 cites W2029928003 @default.
• W3094265721 cites W2034329390 @default.
• W3094265721 cites W2037815393 @default.
• W3094265721 cites W2040024080 @default.
• W3094265721 cites W2043266982 @default.
• W3094265721 cites W2045389096 @default.
• W3094265721 cites W2050067519 @default.
• W3094265721 cites W2051249897 @default.
• W3094265721 cites W2053944784 @default.
• W3094265721 cites W2054266927 @default.
• W3094265721 cites W2054267961 @default.
• W3094265721 cites W2060791667 @default.
• W3094265721 cites W2061358034 @default.
• W3094265721 cites W2061667789 @default.
• W3094265721 cites W2067583313 @default.
• W3094265721 cites W2079020124 @default.
• W3094265721 cites W2079788340 @default.
• W3094265721 cites W2084001142 @default.
• W3094265721 cites W2087705693 @default.
• W3094265721 cites W2091161335 @default.
• W3094265721 cites W2091643218 @default.
• W3094265721 cites W2101467600 @default.
• W3094265721 cites W2103513010 @default.
• W3094265721 cites W2118057169 @default.
• W3094265721 cites W2119221073 @default.
• W3094265721 cites W2122967659 @default.
• W3094265721 cites W2123674503 @default.
• W3094265721 cites W2138913588 @default.
• W3094265721 cites W2147099985 @default.
• W3094265721 cites W2147255658 @default.
• W3094265721 cites W2147673480 @default.
• W3094265721 cites W2164195941 @default.
• W3094265721 cites W2170728568 @default.
• W3094265721 cites W2223695027 @default.
• W3094265721 cites W2319401059 @default.
• W3094265721 cites W2326964709 @default.
• W3094265721 cites W2343621063 @default.
• W3094265721 cites W2604417433 @default.
• W3094265721 cites W2729613231 @default.
• W3094265721 cites W2783846592 @default.
• W3094265721 cites W2807061913 @default.
• W3094265721 cites W2890343309 @default.
• W3094265721 cites W2897427751 @default.
• W3094265721 cites W2908959823 @default.
• W3094265721 cites W2914371319 @default.
• W3094265721 cites W2952640626 @default.
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• W3094265721 cites W2997704321 @default.
• W3094265721 cites W4210252551 @default.
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• W3094265721 doi "https://doi.org/10.3390/molecules25214914" @default.
• W3094265721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7660628" @default.
• W3094265721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33114252" @default.
• W3094265721 hasPublicationYear "2020" @default.
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