FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094313612> ?p ?o ?g. }

• W3094313612 endingPage "9303" @default.
• W3094313612 startingPage "9298" @default.
• W3094313612 abstract "The discovery of RNA enzymes, ribozymes, provided strong support to the RNA world hypothesis suggesting that early life evolved from RNAs able to both store genetic information and catalyze biochemical reactions. Moreover, evidence is accumulating that primitive life might have emerged in deep-sea environments and, thus, at high hydrostatic pressures. If true, ribozymes should be able to function under those pressures. In this work, we ask if and possibly how ribozymes could function at high pressures. To this end, we specifically focus on the chemical reaction steps of the self-cleavage catalysis of hairpin ribozyme by employing extensive QM/MM metadynamics simulations. We find that the reaction scenario at high pressures is vastly different than that at ambient conditions, yet the rate-limiting reaction barrier and, thus, the reaction rate are only marginally affected. Therefore, the results indeed suggest that ribozymes would function at high pressures but by following a vastly different reaction scenario." @default.
• W3094313612 created "2020-10-29" @default.
• W3094313612 creator A5032050383 @default.
• W3094313612 creator A5072717593 @default.
• W3094313612 date "2020-10-21" @default.
• W3094313612 modified "2023-09-25" @default.
• W3094313612 title "On the Adaptability of the Chemical Reaction of Hairpin Ribozyme to High Pressures" @default.
• W3094313612 cites W1560814940 @default.
• W3094313612 cites W1629360817 @default.
• W3094313612 cites W1964241051 @default.
• W3094313612 cites W1966015273 @default.
• W3094313612 cites W1971024314 @default.
• W3094313612 cites W1971589546 @default.
• W3094313612 cites W1980410097 @default.
• W3094313612 cites W1983744996 @default.
• W3094313612 cites W1987287995 @default.
• W3094313612 cites W1997424362 @default.
• W3094313612 cites W2008428327 @default.
• W3094313612 cites W2019555480 @default.
• W3094313612 cites W2029689723 @default.
• W3094313612 cites W2038354555 @default.
• W3094313612 cites W2045389438 @default.
• W3094313612 cites W2049341496 @default.
• W3094313612 cites W2050110866 @default.
• W3094313612 cites W2069348762 @default.
• W3094313612 cites W2081046982 @default.
• W3094313612 cites W2102032812 @default.
• W3094313612 cites W2110872379 @default.
• W3094313612 cites W2131288855 @default.
• W3094313612 cites W2136729627 @default.
• W3094313612 cites W2146184097 @default.
• W3094313612 cites W2149655632 @default.
• W3094313612 cites W2164701497 @default.
• W3094313612 cites W2167470206 @default.
• W3094313612 cites W2275900200 @default.
• W3094313612 cites W2324459447 @default.
• W3094313612 cites W2327005453 @default.
• W3094313612 cites W2394495819 @default.
• W3094313612 cites W2603709419 @default.
• W3094313612 cites W2766412919 @default.
• W3094313612 cites W2884256868 @default.
• W3094313612 cites W2887693603 @default.
• W3094313612 cites W2889678688 @default.
• W3094313612 cites W2946808414 @default.
• W3094313612 cites W2988140817 @default.
• W3094313612 cites W2994252584 @default.
• W3094313612 cites W3001132921 @default.
• W3094313612 cites W3005892601 @default.
• W3094313612 cites W3012602205 @default.
• W3094313612 cites W3031721950 @default.
• W3094313612 cites W4253399616 @default.
• W3094313612 doi "https://doi.org/10.1021/acs.jpclett.0c02902" @default.
• W3094313612 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33085887" @default.
• W3094313612 hasPublicationYear "2020" @default.
• W3094313612 type Work @default.
• W3094313612 sameAs 3094313612 @default.
• W3094313612 citedByCount "2" @default.
• W3094313612 countsByYear W30943136122022 @default.
• W3094313612 crossrefType "journal-article" @default.
• W3094313612 hasAuthorship W3094313612A5032050383 @default.
• W3094313612 hasAuthorship W3094313612A5072717593 @default.
• W3094313612 hasConcept C104317684 @default.
• W3094313612 hasConcept C107745601 @default.
• W3094313612 hasConcept C121332964 @default.
• W3094313612 hasConcept C12554922 @default.
• W3094313612 hasConcept C1342335 @default.
• W3094313612 hasConcept C14036430 @default.
• W3094313612 hasConcept C147597530 @default.
• W3094313612 hasConcept C161790260 @default.
• W3094313612 hasConcept C175113610 @default.
• W3094313612 hasConcept C185592680 @default.
• W3094313612 hasConcept C2910081258 @default.
• W3094313612 hasConcept C55493867 @default.
• W3094313612 hasConcept C59593255 @default.
• W3094313612 hasConcept C62752575 @default.
• W3094313612 hasConcept C67705224 @default.
• W3094313612 hasConcept C76346623 @default.
• W3094313612 hasConcept C86803240 @default.
• W3094313612 hasConcept C95444343 @default.
• W3094313612 hasConcept C97355855 @default.
• W3094313612 hasConceptScore W3094313612C104317684 @default.
• W3094313612 hasConceptScore W3094313612C107745601 @default.
• W3094313612 hasConceptScore W3094313612C121332964 @default.
• W3094313612 hasConceptScore W3094313612C12554922 @default.
• W3094313612 hasConceptScore W3094313612C1342335 @default.
• W3094313612 hasConceptScore W3094313612C14036430 @default.
• W3094313612 hasConceptScore W3094313612C147597530 @default.
• W3094313612 hasConceptScore W3094313612C161790260 @default.
• W3094313612 hasConceptScore W3094313612C175113610 @default.
• W3094313612 hasConceptScore W3094313612C185592680 @default.
• W3094313612 hasConceptScore W3094313612C2910081258 @default.
• W3094313612 hasConceptScore W3094313612C55493867 @default.
• W3094313612 hasConceptScore W3094313612C59593255 @default.
• W3094313612 hasConceptScore W3094313612C62752575 @default.
• W3094313612 hasConceptScore W3094313612C67705224 @default.
• W3094313612 hasConceptScore W3094313612C76346623 @default.
• W3094313612 hasConceptScore W3094313612C86803240 @default.
• W3094313612 hasConceptScore W3094313612C95444343 @default.

• next