FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094331348> ?p ?o ?g. }

• W3094331348 endingPage "e571" @default.
• W3094331348 startingPage "e571" @default.
• W3094331348 abstract "Peak dose has been used for treatment prescription in all forms of Spatially-Fractionated Radiation Therapy (SFRT) including clinical GRID and Lattice therapy and preclinical microbeam and minibeam therapy. Peak width, valley width and dose, volume-average dose, peak dose to valley dose ratio, and EUDs are also used to characterize the complex SFRT dosimetry. Currently there is a lack of understanding which of these SFRT dosimetric parameters have close correlation with a given clinical outcome and thus should be used for treatment prescription. In this preclinical study we correlate treatment responses (tumor response and body weight change, an indicator of treatment toxicity) with each of the dosimetric parameters in a carefully designed study where a large range of radiation spatial fractionation scale is used. Five study arms (uniform tumor radiation, half-tumor radiation, 2mm beam array radiation, and 0.3mm minibeam radiation) each with 20Gy average dose, a 50 Gy minibeam and untreated arms were used. A 320kV x-ray irradiator was used. Forty-two female Fischer 344 rats with fibrosarcoma tumor allografts were used. Dosimetric parameters studied are peak dose and width, valley dose and width, peak-to-valley-dose-ratio, volumetric average dose, percentage volume directly irradiated, and tumor- and normal-tissue EUD. Animal survival, tumor volume change, and body weight change (indicative of treatment toxicity) are tested for association with the dosimetric parameters using linear regression and Cox Proportional Hazards models. The dosimetric parameters most closely associated with tumor response are tumor EUD (R2 = 0.792, F-stat = 15.26*; z-test = -4.07***), valley/minimum dose (R2 = 0.764, F-stat = 12.92*; z-test = -4.34***), and percentage tumor directly irradiated (R2 = 0.715, F-stat = 10.05*; z-test = -3.84***) per the linear regression and Cox Proportional Hazards models, respectively. Tumor response is linearly proportional to valley/minimum doses and tumor EUD. Volume average dose (R2 = 0.275, F-stat = 1.514 (no sig.); z-test = -2.81**) and peak dose (R2 = 0.045, F-stat = 0.687 (not sig.); z-test = -0.786 (not sig.)) show the weakest associations to tumor response. Only the uniform radiation arm did not gain body weight post-radiation; however, body weight change in general shows weak association with all dosimetric parameters except for valley/min dose (R2 = 0.381, F-stat = 13.56**), valley width (R2 = 0.285, F-stat = 8.78**), and peak width (R2 = 0.276, F-stat = 8.38**). For a single-fraction SFRT at conventional dose rates, valley dose is closely associated with tumor treatment response. Tumor EUD, valley/min dose, and percentage tumor directly irradiated are the top three dosimetric parameters that exhibited close associations with tumor response. Peak dose showed the weakest correlation with tumor treatment response. Our study suggests that valley dose, not peak dose, should be used for SFRT treatment prescription." @default.
• W3094331348 created "2020-10-29" @default.
• W3094331348 creator A5014953708 @default.
• W3094331348 creator A5048815205 @default.
• W3094331348 creator A5056344532 @default.
• W3094331348 creator A5061274866 @default.
• W3094331348 creator A5069018587 @default.
• W3094331348 creator A5084515264 @default.
• W3094331348 date "2020-11-01" @default.
• W3094331348 modified "2023-10-16" @default.
• W3094331348 title "Should We Use Peak Dose To Prescribe A Spatially-Fractionated Radiation Therapy (SFRT) Treatment?" @default.
• W3094331348 doi "https://doi.org/10.1016/j.ijrobp.2020.07.1760" @default.
• W3094331348 hasPublicationYear "2020" @default.
• W3094331348 type Work @default.
• W3094331348 sameAs 3094331348 @default.
• W3094331348 citedByCount "0" @default.
• W3094331348 crossrefType "journal-article" @default.
• W3094331348 hasAuthorship W3094331348A5014953708 @default.
• W3094331348 hasAuthorship W3094331348A5048815205 @default.
• W3094331348 hasAuthorship W3094331348A5056344532 @default.
• W3094331348 hasAuthorship W3094331348A5061274866 @default.
• W3094331348 hasAuthorship W3094331348A5069018587 @default.
• W3094331348 hasAuthorship W3094331348A5084515264 @default.
• W3094331348 hasBestOaLocation W30943313481 @default.
• W3094331348 hasConcept C125118446 @default.
• W3094331348 hasConcept C126838900 @default.
• W3094331348 hasConcept C142724271 @default.
• W3094331348 hasConcept C155806632 @default.
• W3094331348 hasConcept C2776495794 @default.
• W3094331348 hasConcept C2989005 @default.
• W3094331348 hasConcept C509974204 @default.
• W3094331348 hasConcept C71924100 @default.
• W3094331348 hasConcept C75088862 @default.
• W3094331348 hasConceptScore W3094331348C125118446 @default.
• W3094331348 hasConceptScore W3094331348C126838900 @default.
• W3094331348 hasConceptScore W3094331348C142724271 @default.
• W3094331348 hasConceptScore W3094331348C155806632 @default.
• W3094331348 hasConceptScore W3094331348C2776495794 @default.
• W3094331348 hasConceptScore W3094331348C2989005 @default.
• W3094331348 hasConceptScore W3094331348C509974204 @default.
• W3094331348 hasConceptScore W3094331348C71924100 @default.
• W3094331348 hasConceptScore W3094331348C75088862 @default.
• W3094331348 hasIssue "3" @default.
• W3094331348 hasLocation W30943313481 @default.
• W3094331348 hasOpenAccess W3094331348 @default.
• W3094331348 hasPrimaryLocation W30943313481 @default.
• W3094331348 hasRelatedWork W1919433043 @default.
• W3094331348 hasRelatedWork W1983863207 @default.
• W3094331348 hasRelatedWork W2050145840 @default.
• W3094331348 hasRelatedWork W2056554831 @default.
• W3094331348 hasRelatedWork W2377870086 @default.
• W3094331348 hasRelatedWork W2796229980 @default.
• W3094331348 hasRelatedWork W3005748790 @default.
• W3094331348 hasRelatedWork W3029539430 @default.
• W3094331348 hasRelatedWork W3035773300 @default.
• W3094331348 hasRelatedWork W4233562436 @default.
• W3094331348 hasVolume "108" @default.
• W3094331348 isParatext "false" @default.
• W3094331348 isRetracted "false" @default.
• W3094331348 magId "3094331348" @default.
• W3094331348 workType "article" @default.