Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094351996> ?p ?o ?g. }
- W3094351996 abstract "ABSTRACT The RNA chaperone Hfq regulates diverse processes in numerous bacteria. In this study, we compared phenotypes (growth rate, adherence, response to different stress conditions and virulence in Galleria mellonella) of wild-type (WT) and isogenic hfq mutants of three serovars (1, 8 and 15) of the porcine pathogen Actinobacillus pleuropneumoniae. Similar growth in rich broth was seen for all strains except Ap1∆hfq, which showed slightly reduced growth throughout the 24 h time course, and the complemented Ap8∆hfqC mutant had a prolonged lag phase. Differences were seen between the three serovar WT strains regarding adherence, stress response and virulence in G. mellonella, and deletion of hfq affected some, but not all of these phenotypes, depending on serovar. Complementation by expression of cloned hfq from an endogenous promoter only restored some WT phenotypes, indicating that complex regulatory networks may be involved, and that levels of Hfq may be as important as presence/absence of the protein regarding its contribution to gene regulation. Our results support that Hfq is a pleiotropic global regulator in A. pleuropneumoniae, but serovar-related differences exist. These results highlight the importance of testing multiple strains/serovars within a given species when determining contributions of global regulators, such as Hfq, to expression of complex phenotypes." @default.
- W3094351996 created "2020-10-29" @default.
- W3094351996 creator A5013041073 @default.
- W3094351996 creator A5018526489 @default.
- W3094351996 creator A5021221641 @default.
- W3094351996 creator A5023116254 @default.
- W3094351996 creator A5023693692 @default.
- W3094351996 creator A5034055809 @default.
- W3094351996 creator A5035246020 @default.
- W3094351996 creator A5052411494 @default.
- W3094351996 creator A5061038371 @default.
- W3094351996 creator A5070238848 @default.
- W3094351996 creator A5075913374 @default.
- W3094351996 creator A5090057049 @default.
- W3094351996 creator A5091532893 @default.
- W3094351996 date "2020-10-23" @default.
- W3094351996 modified "2023-10-17" @default.
- W3094351996 title "Serovar-dependent differences in Hfq-regulated phenotypes in<i>Actinobacillus pleuropneumoniae</i>" @default.
- W3094351996 cites W1577561851 @default.
- W3094351996 cites W1814930618 @default.
- W3094351996 cites W1966488573 @default.
- W3094351996 cites W1970231046 @default.
- W3094351996 cites W1980780067 @default.
- W3094351996 cites W1986376237 @default.
- W3094351996 cites W1989781175 @default.
- W3094351996 cites W1994050060 @default.
- W3094351996 cites W2007098775 @default.
- W3094351996 cites W2014372073 @default.
- W3094351996 cites W2018107512 @default.
- W3094351996 cites W2023605769 @default.
- W3094351996 cites W2029176287 @default.
- W3094351996 cites W2031487425 @default.
- W3094351996 cites W2031668975 @default.
- W3094351996 cites W2032532106 @default.
- W3094351996 cites W2043558473 @default.
- W3094351996 cites W2045807020 @default.
- W3094351996 cites W2062567955 @default.
- W3094351996 cites W2065862361 @default.
- W3094351996 cites W2069000180 @default.
- W3094351996 cites W2071421668 @default.
- W3094351996 cites W2073757265 @default.
- W3094351996 cites W2076790002 @default.
- W3094351996 cites W2079347492 @default.
- W3094351996 cites W2100009016 @default.
- W3094351996 cites W2100339690 @default.
- W3094351996 cites W2100513000 @default.
- W3094351996 cites W2101802045 @default.
- W3094351996 cites W2102044733 @default.
- W3094351996 cites W2104243549 @default.
- W3094351996 cites W2116443594 @default.
- W3094351996 cites W2116667670 @default.
- W3094351996 cites W2137369730 @default.
- W3094351996 cites W2143089662 @default.
- W3094351996 cites W2151451423 @default.
- W3094351996 cites W2152663254 @default.
- W3094351996 cites W2154082031 @default.
- W3094351996 cites W2154767427 @default.
- W3094351996 cites W2155790181 @default.
- W3094351996 cites W2166406784 @default.
- W3094351996 cites W2172280102 @default.
- W3094351996 cites W2177724843 @default.
- W3094351996 cites W2197895074 @default.
- W3094351996 cites W2211028390 @default.
- W3094351996 cites W2254260734 @default.
- W3094351996 cites W2263441127 @default.
- W3094351996 cites W2267288610 @default.
- W3094351996 cites W2274446099 @default.
- W3094351996 cites W2284159252 @default.
- W3094351996 cites W2573883534 @default.
- W3094351996 cites W2767189590 @default.
- W3094351996 cites W2790164744 @default.
- W3094351996 cites W2794314732 @default.
- W3094351996 cites W2802939828 @default.
- W3094351996 cites W2808480264 @default.
- W3094351996 cites W2945815787 @default.
- W3094351996 doi "https://doi.org/10.1093/femspd/ftaa066" @default.
- W3094351996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33095236" @default.
- W3094351996 hasPublicationYear "2020" @default.
- W3094351996 type Work @default.
- W3094351996 sameAs 3094351996 @default.
- W3094351996 citedByCount "7" @default.
- W3094351996 countsByYear W30943519962021 @default.
- W3094351996 countsByYear W30943519962022 @default.
- W3094351996 crossrefType "journal-article" @default.
- W3094351996 hasAuthorship W3094351996A5013041073 @default.
- W3094351996 hasAuthorship W3094351996A5018526489 @default.
- W3094351996 hasAuthorship W3094351996A5021221641 @default.
- W3094351996 hasAuthorship W3094351996A5023116254 @default.
- W3094351996 hasAuthorship W3094351996A5023693692 @default.
- W3094351996 hasAuthorship W3094351996A5034055809 @default.
- W3094351996 hasAuthorship W3094351996A5035246020 @default.
- W3094351996 hasAuthorship W3094351996A5052411494 @default.
- W3094351996 hasAuthorship W3094351996A5061038371 @default.
- W3094351996 hasAuthorship W3094351996A5070238848 @default.
- W3094351996 hasAuthorship W3094351996A5075913374 @default.
- W3094351996 hasAuthorship W3094351996A5090057049 @default.
- W3094351996 hasAuthorship W3094351996A5091532893 @default.
- W3094351996 hasBestOaLocation W30943519961 @default.
- W3094351996 hasConcept C10389963 @default.
- W3094351996 hasConcept C104317684 @default.