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• W3094367028 abstract "The Wnt signalling pathways are composed of a highly conserved cascade of events that govern cell differentiation, apoptosis and cell orientation. Three major and distinct Wnt signalling pathways have been characterized: the canonical Wnt pathway (or Wnt/β-catenin pathway), the non-canonical planar cell polarity pathway and the non-canonical Wnt/Ca 2+ pathway. Altered Wnt signalling pathway has been associated with diverse diseases such as disorders of bone density, different malignancies, cardiac malformations and heart failure. Coronary artery disease is the most common type of heart disease in the United States. Atherosclerosis is a multi-step pathological process, which starts with lipid deposition and endothelial cell dysfunction, triggering inflammatory reactions, followed by recruitment and aggregation of monocytes. Subsequently, monocytes differentiate into tissue-resident macrophages and transform into foam cells by the uptake of modified low-density lipoprotein. Meanwhile, further accumulations of lipids, infiltration and proliferation of vascular smooth muscle cells, and deposition of the extracellular matrix occur under the intima. An atheromatous plaque or hyperplasia of the intima and media is eventually formed, resulting in luminal narrowing and reduced blood flow to the myocardium, leading to chest pain, angina and even myocardial infarction. The Wnt pathway participates in all different stages of this process, from endothelial dysfunction to lipid deposit, and from initial inflammation to plaque formation. Here, we focus on the role of Wnt cascade in pathophysiological mechanisms that take part in coronary artery disease from both clinical and experimental perspectives." @default.
• W3094367028 created "2020-10-29" @default.
• W3094367028 creator A5041279122 @default.
• W3094367028 creator A5089611409 @default.
• W3094367028 creator A5091753218 @default.
• W3094367028 date "2020-10-01" @default.
• W3094367028 modified "2023-10-05" @default.
• W3094367028 title "The role of Wnt signalling in development of coronary artery disease and its risk factors" @default.
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• W3094367028 doi "https://doi.org/10.1098/rsob.200128" @default.
• W3094367028 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7653355" @default.
• W3094367028 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33081636" @default.
• W3094367028 hasPublicationYear "2020" @default.
• W3094367028 type Work @default.
• W3094367028 sameAs 3094367028 @default.

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