Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094367033> ?p ?o ?g. }
- W3094367033 abstract "In this study, we analyzed full-length SARS-CoV-2 genomes from multiple countries to determine early trends in the evolutionary dynamics of the novel COVID-19 pandemic. Results indicated SARS-CoV-2 evolved early into at least three phylogenetic groups, characterized by positive selection at specific residues of the accessory proteins ORF3a and ORF8. Also, we are reporting potential relevant sites under positive selection at specific sites of non-structural proteins nsp6 and helicase. Our analysis of co-evolution showed evidence of epistatic interactions among sites in the genome that may be important in the generation of variants adapted to humans. These observations might impact not only public health but also suggest that more studies are needed to understand the genetic mechanisms that may affect the development of therapeutic and preventive tools, like antivirals and vaccines. Collectively, our results highlight the identification of ongoing selection even in a scenario of conserved sequences collected over the first 3 months of this pandemic." @default.
- W3094367033 created "2020-10-29" @default.
- W3094367033 creator A5000172111 @default.
- W3094367033 creator A5025057768 @default.
- W3094367033 creator A5025362774 @default.
- W3094367033 creator A5025822842 @default.
- W3094367033 creator A5033941931 @default.
- W3094367033 creator A5063313427 @default.
- W3094367033 date "2020-10-23" @default.
- W3094367033 modified "2023-10-17" @default.
- W3094367033 title "Positive Selection of ORF1ab, ORF3a, and ORF8 Genes Drives the Early Evolutionary Trends of SARS-CoV-2 During the 2020 COVID-19 Pandemic" @default.
- W3094367033 cites W1908810753 @default.
- W3094367033 cites W1985360059 @default.
- W3094367033 cites W1987906244 @default.
- W3094367033 cites W1993167804 @default.
- W3094367033 cites W2009596137 @default.
- W3094367033 cites W2014164467 @default.
- W3094367033 cites W2018114360 @default.
- W3094367033 cites W2056265093 @default.
- W3094367033 cites W2069760687 @default.
- W3094367033 cites W2079502702 @default.
- W3094367033 cites W2096420865 @default.
- W3094367033 cites W2108512869 @default.
- W3094367033 cites W2112011866 @default.
- W3094367033 cites W2118982822 @default.
- W3094367033 cites W2123063376 @default.
- W3094367033 cites W2124802250 @default.
- W3094367033 cites W2127100712 @default.
- W3094367033 cites W2130362098 @default.
- W3094367033 cites W2131988685 @default.
- W3094367033 cites W2134250657 @default.
- W3094367033 cites W2136847298 @default.
- W3094367033 cites W2138178197 @default.
- W3094367033 cites W2140028978 @default.
- W3094367033 cites W2143210482 @default.
- W3094367033 cites W2146058063 @default.
- W3094367033 cites W2157256056 @default.
- W3094367033 cites W2161444534 @default.
- W3094367033 cites W2309963042 @default.
- W3094367033 cites W2311203695 @default.
- W3094367033 cites W2406445961 @default.
- W3094367033 cites W2497200535 @default.
- W3094367033 cites W2531793945 @default.
- W3094367033 cites W2538584349 @default.
- W3094367033 cites W2746487413 @default.
- W3094367033 cites W2777914188 @default.
- W3094367033 cites W2781938185 @default.
- W3094367033 cites W2801159594 @default.
- W3094367033 cites W2802880935 @default.
- W3094367033 cites W2885957031 @default.
- W3094367033 cites W2905286853 @default.
- W3094367033 cites W2948824749 @default.
- W3094367033 cites W2984657051 @default.
- W3094367033 cites W3003217347 @default.
- W3094367033 cites W3004348779 @default.
- W3094367033 cites W3006936240 @default.
- W3094367033 cites W3009906937 @default.
- W3094367033 cites W3010466793 @default.
- W3094367033 cites W3011127849 @default.
- W3094367033 cites W3012565918 @default.
- W3094367033 cites W3014450743 @default.
- W3094367033 cites W3015444032 @default.
- W3094367033 cites W3021396888 @default.
- W3094367033 cites W3021922824 @default.
- W3094367033 cites W3022498108 @default.
- W3094367033 cites W3026367382 @default.
- W3094367033 cites W3034070831 @default.
- W3094367033 cites W3034927885 @default.
- W3094367033 cites W3036178624 @default.
- W3094367033 cites W3048671222 @default.
- W3094367033 cites W4241060704 @default.
- W3094367033 doi "https://doi.org/10.3389/fmicb.2020.550674" @default.
- W3094367033 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7644918" @default.
- W3094367033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33193132" @default.
- W3094367033 hasPublicationYear "2020" @default.
- W3094367033 type Work @default.
- W3094367033 sameAs 3094367033 @default.
- W3094367033 citedByCount "90" @default.
- W3094367033 countsByYear W30943670332020 @default.
- W3094367033 countsByYear W30943670332021 @default.
- W3094367033 countsByYear W30943670332022 @default.
- W3094367033 countsByYear W30943670332023 @default.
- W3094367033 crossrefType "journal-article" @default.
- W3094367033 hasAuthorship W3094367033A5000172111 @default.
- W3094367033 hasAuthorship W3094367033A5025057768 @default.
- W3094367033 hasAuthorship W3094367033A5025362774 @default.
- W3094367033 hasAuthorship W3094367033A5025822842 @default.
- W3094367033 hasAuthorship W3094367033A5033941931 @default.
- W3094367033 hasAuthorship W3094367033A5063313427 @default.
- W3094367033 hasBestOaLocation W30943670331 @default.
- W3094367033 hasConcept C104317684 @default.
- W3094367033 hasConcept C116834253 @default.
- W3094367033 hasConcept C141231307 @default.
- W3094367033 hasConcept C142724271 @default.
- W3094367033 hasConcept C154945302 @default.
- W3094367033 hasConcept C171578705 @default.
- W3094367033 hasConcept C18903297 @default.
- W3094367033 hasConcept C193252679 @default.
- W3094367033 hasConcept C2779134260 @default.
- W3094367033 hasConcept C2908647359 @default.