FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094392334> ?p ?o ?g. }

• W3094392334 endingPage "e556" @default.
• W3094392334 startingPage "e555" @default.
• W3094392334 abstract "The purpose of this study was to evaluate the individual radiosensitivity by analyzing the DNA damage response and chromosomal aberrations (CAs) in peripheral blood lymphocytes (PBLs) induced by chemoradiotherapy (CRT) and to predict non-hematologic acute toxicities of CRT in patients with esophageal cancer. Sixteen esophageal cancer patients referred to our institution for definitive CRT were enrolled in this prospective study. Prescribed doses were 60 Gy in 10 patients and 50 Gy in 6 patients. Patients received 2 Gy radiotherapy (RT) five days a week. Cisplatin or Nedaplatin (days 1 and 29) and 5-fluorouracil (days 1–4 and 29–32) were used as chemotherapy. PBLs were obtained during treatment just before and 15 minutes after delivering 2 Gy of RT on the day when the cumulative dose reached 2, 20, 40 and 50/60 Gy. PBLs were also obtained 4 weeks and 6 months after RT from all and thirteen patients, respectively. Dicentric and ring chromosomes in PBLs were counted to evaluate the numbers of CAs. γ-H2AX foci per cell were counted and the increment of γ-H2AX foci by 2 Gy RT was examined to assess DNA double-strand breaks. We assessed the association between these factors and adverse events of CRT evaluated using common terminology criteria for adverse events version 5.0. Paired t-test adjusted by Bonferroni correction and Mann-Whitney U test were used to compare the indices from the same group at different timings and the indices between two groups, respectively. For all analyses, a P value of < 0.05 was considered significant. The mean numbers of CAs per 1,000 cells increased during CRT and decreased after RT: before RT, 13 (range: 0–24); 2 Gy, 50 (31–82); 20 Gy, 442 (218–1,099); 40 Gy: 710 (338–1,333); the last day of RT (50 or 60 Gy), 1,089 (567–2,295); 4 weeks after RT: 1,019 (455–2,063); and 6 months after RT: 646 (269–1,217). The mean numbers of γH2AX foci per cell before RT showed no increase during CRT. The mean increment of γH2AX foci per cell by 2 Gy RT was significantly reduced with accumulation of RT dose: 2Gy, 1.95 (0.57–3.33); 20 Gy, 1.70(0.59–3.17); 40 Gy: 1.01 (0.06–1.88); and the last day of RT (50 or 60 Gy), 0.69 (0.08–2.19), even though the same dose was administered each day. Five patients showed grade 3 toxicities during or after CRT (overreactors: OR), while eleven had grade 2 or less toxicities (non-overreactors: NOR). The numbers of CAs were significantly higher in the OR group than in the NOR group at a cumulative dose of 20 Gy (mean value: 625 vs 355, P = 0.02), 40 Gy (mean value: 903 vs 571, P = 0.04), and the last day of RT (mean value: 1485 vs 869, P = 0.007). The number and increment of γH2AX foci did not show a significant association with acute toxicities. The number of CAs after CRT increased as the cumulative doses increased, while the increment of γ-H2AX foci decreased with an increase in cumulative dose. The number of CAs could be an index for predicting non-hematologic acute toxicities of CRT for esophageal cancer." @default.
• W3094392334 created "2020-10-29" @default.
• W3094392334 creator A5016890878 @default.
• W3094392334 creator A5018115431 @default.
• W3094392334 creator A5024539394 @default.
• W3094392334 creator A5026012433 @default.
• W3094392334 creator A5027962378 @default.
• W3094392334 creator A5031242190 @default.
• W3094392334 creator A5050723918 @default.
• W3094392334 creator A5070079124 @default.
• W3094392334 creator A5071124354 @default.
• W3094392334 creator A5072801244 @default.
• W3094392334 creator A5083969819 @default.
• W3094392334 date "2020-11-01" @default.
• W3094392334 modified "2023-09-26" @default.
• W3094392334 title "Association Between Acute Toxicities Of Chemoradiotherapy And Chromosomal Aberrations In Peripheral Blood Lymphocytes In Esophageal Cancer Patients" @default.
• W3094392334 doi "https://doi.org/10.1016/j.ijrobp.2020.07.1722" @default.
• W3094392334 hasPublicationYear "2020" @default.
• W3094392334 type Work @default.
• W3094392334 sameAs 3094392334 @default.
• W3094392334 citedByCount "0" @default.
• W3094392334 crossrefType "journal-article" @default.
• W3094392334 hasAuthorship W3094392334A5016890878 @default.
• W3094392334 hasAuthorship W3094392334A5018115431 @default.
• W3094392334 hasAuthorship W3094392334A5024539394 @default.
• W3094392334 hasAuthorship W3094392334A5026012433 @default.
• W3094392334 hasAuthorship W3094392334A5027962378 @default.
• W3094392334 hasAuthorship W3094392334A5031242190 @default.
• W3094392334 hasAuthorship W3094392334A5050723918 @default.
• W3094392334 hasAuthorship W3094392334A5070079124 @default.
• W3094392334 hasAuthorship W3094392334A5071124354 @default.
• W3094392334 hasAuthorship W3094392334A5072801244 @default.
• W3094392334 hasAuthorship W3094392334A5083969819 @default.
• W3094392334 hasConcept C121608353 @default.
• W3094392334 hasConcept C126322002 @default.
• W3094392334 hasConcept C143998085 @default.
• W3094392334 hasConcept C197934379 @default.
• W3094392334 hasConcept C2776694085 @default.
• W3094392334 hasConcept C2777793932 @default.
• W3094392334 hasConcept C2778203143 @default.
• W3094392334 hasConcept C2778239845 @default.
• W3094392334 hasConcept C2778424827 @default.
• W3094392334 hasConcept C2779742542 @default.
• W3094392334 hasConcept C509974204 @default.
• W3094392334 hasConcept C71924100 @default.
• W3094392334 hasConcept C90924648 @default.
• W3094392334 hasConceptScore W3094392334C121608353 @default.
• W3094392334 hasConceptScore W3094392334C126322002 @default.
• W3094392334 hasConceptScore W3094392334C143998085 @default.
• W3094392334 hasConceptScore W3094392334C197934379 @default.
• W3094392334 hasConceptScore W3094392334C2776694085 @default.
• W3094392334 hasConceptScore W3094392334C2777793932 @default.
• W3094392334 hasConceptScore W3094392334C2778203143 @default.
• W3094392334 hasConceptScore W3094392334C2778239845 @default.
• W3094392334 hasConceptScore W3094392334C2778424827 @default.
• W3094392334 hasConceptScore W3094392334C2779742542 @default.
• W3094392334 hasConceptScore W3094392334C509974204 @default.
• W3094392334 hasConceptScore W3094392334C71924100 @default.
• W3094392334 hasConceptScore W3094392334C90924648 @default.
• W3094392334 hasIssue "3" @default.
• W3094392334 hasLocation W30943923341 @default.
• W3094392334 hasOpenAccess W3094392334 @default.
• W3094392334 hasPrimaryLocation W30943923341 @default.
• W3094392334 hasRelatedWork W151172257 @default.
• W3094392334 hasRelatedWork W1600642262 @default.
• W3094392334 hasRelatedWork W2045565271 @default.
• W3094392334 hasRelatedWork W2348325681 @default.
• W3094392334 hasRelatedWork W2384018637 @default.
• W3094392334 hasRelatedWork W2404042595 @default.
• W3094392334 hasRelatedWork W2409011989 @default.
• W3094392334 hasRelatedWork W2411066725 @default.
• W3094392334 hasRelatedWork W3021135223 @default.
• W3094392334 hasRelatedWork W3031689446 @default.
• W3094392334 hasVolume "108" @default.
• W3094392334 isParatext "false" @default.
• W3094392334 isRetracted "false" @default.
• W3094392334 magId "3094392334" @default.
• W3094392334 workType "article" @default.