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- W3094397943 abstract "Local application of hyperthermia has a myriad of effects on the tumor microenvironment as well as the host's immune system. Ablative hyperthermia (typically > 55 °C) has been used both as monotherapy and adjuvant therapy, while mild hyperthermia treatment (39–45 °C) demonstrated efficacy as an adjuvant therapy through enhancement of both chemotherapy and radiation therapy. Clinical integration of hyperthermia has especially great potential in pediatric oncology, where current chemotherapy regimens have reached maximum tolerability and the young age of patients implies significant risks of late effects related to therapy. Furthermore, activation of both local and systemic immune response by hyperthermia suggests that hyperthermia treatments could be used to enhance the anticancer effects of immunotherapy. This review summarizes the state of current applications of hyperthermia in pediatric oncology and discusses the use of hyperthermia in the context of other available treatments and promising pre-clinical research." @default.
- W3094397943 created "2020-10-29" @default.
- W3094397943 creator A5004791506 @default.
- W3094397943 creator A5044409970 @default.
- W3094397943 creator A5051977309 @default.
- W3094397943 creator A5085463853 @default.
- W3094397943 date "2020-01-01" @default.
- W3094397943 modified "2023-10-16" @default.
- W3094397943 title "Emerging hyperthermia applications for pediatric oncology" @default.
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