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• W3094432201 abstract "Abstract Purpose Postmastectomy radiation therapy (PMRT) in T1–T2 tumors with 1–3 positive axillary lymph nodes (ALNs) is controversial. This study was to identify prognostic factors of locoregional control (LRC) following mastectomy with or without PMRT for patients with T1-2N1 breast cancer and to discuss the selection of patients who might omit PMRT. Materials and methods Between January 2006 and December 2012, the data of 1474 postmastectomy patients staged pT1-2N1 were analyzed. PMRT was applied in 663 patients. LRC and disease-free survival (DFS) were calculated using the Kaplan–Meier method. Cox regression model was applied in the univariate and multivariate analyses to recognize the recurrence risk factors. Results With the median follow-up duration of 93 months (range, 5–168 months), 78 patients (5.3%) failed to secure LRC and 220 patients (14.9%) experienced any recurrence. The 7.7-year LRC and DFS was 94.9% and 85.4% respectively in the entire cohort. PMRT significantly improved 7.7-year LRC from 93.4% to 96.6% ( p = 0.005), but not the DFS ( p = 0.335). Multivariate analysis revealed that PMRT was an independent prognostic factor of LRC ( p < 0.001), meanwhile, age ≤ 40 years ( p = 0.012), histological grade 3 ( p = 0.004), 2–3 positive nodes ( p < 0.001) and tumor size of 3–5 cm ( p = 0.045) were significantly associated with decreased LRC. The 7.7-year LRC for patients with 0, 1, and 2–4 risk factors was 97.7% / 98.9% ( p = 0.233), 95.3% / 98.0% ( p = 0.092), and 80.3% / 94.8% ( p < 0.001) in the non-PMRT and PMRT group, respectively. Conclusions In patients with T1-2N1 breast cancer, clinical-pathological factors including young age, histological grade 3, 2–3 positive nodes, and tumor size of 3–5 cm were identified to be predictors of a poorer LRC following mastectomy. Patients with 0–1 risk factor might consider the omission of PMRT." @default.
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• W3094432201 date "2021-09-06" @default.
• W3094432201 modified "2023-10-16" @default.
• W3094432201 title "Impact of clinical-pathological factors on locoregional recurrence in mastectomy patients with T1-2N1 breast cancer: who can omit adjuvant radiotherapy?" @default.
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• W3094432201 doi "https://doi.org/10.1007/s10549-021-06378-2" @default.
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