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• W3094449572 abstract "Abstract HIV‐1 RT is a necessary enzyme for retroviral replication, which is the main target for antiviral therapy against AIDS. Effective anti‐HIV‐1 RT drugs are divided into two groups; nucleoside inhibitors (NRTI) and non‐nucleoside inhibitors (NNRTI), which inhibit DNA polymerase. In this study, new DNA aptamers were isolated as anti‐HIV‐1 RT inhibitors. The selected DNA aptamer (WT62) presented with high affinity and inhibition against wild‐type (WT) HIV‐1 RT and gave a KD value of 75.10±0.29 nM and an IC 50 value of 84.81±8.54 nM. Moreover, WT62 decreased the DNA polymerase function of K103 N/Y181 C double mutant (KY) HIV‐1 RT by around 80 %. Furthermore, the ITC results showed that this aptamer has small binding enthalpies with both WT and KY HIV‐1 RTs through which the complex might form a hydrophobic interaction or noncovalent bonding. The NMR result also suggested that the WT62 aptamer could bind with both WT and KY mutant HIV‐1 RTs at the connection domain." @default.
• W3094449572 created "2020-10-29" @default.
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• W3094449572 date "2020-11-30" @default.
• W3094449572 modified "2023-10-17" @default.
• W3094449572 title "Characterization of New DNA Aptamers for Anti‐HIV‐1 Reverse Transcriptase" @default.
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• W3094449572 doi "https://doi.org/10.1002/cbic.202000633" @default.
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