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• W3094465718 abstract "The emergence of antibiotic tolerance enables genetically susceptible bacteria to withstand the killing by clinically relevant antibiotics. As is reported, an increasing body of evidence sheds light on the critical and underappreciated role of antibiotic tolerance in the disease burden of bacterial infections. Considering this tense situation, new therapeutic strategies are urgently required for combating antibiotic tolerance. Herein, we provide an insightful illustration to distinguish between antibiotic resistance and tolerance, and highlight its clinical significance and complexities of drug-tolerant bacteria. Then, we discuss the close relationship between antibiotic tolerance and bacterial metabolism. As such, a bacterial metabolism-based approach was proposed to counter antibiotic tolerance. These exogenous metabolites including amino acids, tricarboxylic cycle (TCA cycle) metabolites and nucleotides, effectively activate bacterial metabolism and convert the tolerant cells to sensitive cells, and eventually restore antibiotic efficacy. A better understanding of molecular mechanisms of antibiotic tolerance particularly in vivo would substantially drive the development of novel strategies targeting bacterial metabolism." @default.
• W3094465718 created "2020-10-29" @default.
• W3094465718 creator A5002784098 @default.
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• W3094465718 creator A5054358636 @default.
• W3094465718 creator A5078382285 @default.
• W3094465718 date "2020-10-22" @default.
• W3094465718 modified "2023-10-14" @default.
• W3094465718 title "Combating Antibiotic Tolerance Through Activating Bacterial Metabolism" @default.
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• W3094465718 doi "https://doi.org/10.3389/fmicb.2020.577564" @default.
• W3094465718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7642520" @default.
• W3094465718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33193198" @default.
• W3094465718 hasPublicationYear "2020" @default.
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