FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094483448> ?p ?o ?g. }

• W3094483448 endingPage "43" @default.
• W3094483448 startingPage "34" @default.
• W3094483448 abstract "T-cell lymphoid malignancies (TCLMs) are in need of novel and more effective therapies. The histone deacetylase (HDAC) inhibitors and the synthetic cytotoxic retinoid fenretinide have achieved durable clinical responses in T-cell lymphomas as single agents, and patients who failed prior HDAC inhibitor treatment have responded to fenretinide. We have previously shown fenretinide synergized with the class I HDAC inhibitor romidepsin in preclinical models of TCLMs. There exist some key differences between HDAC inhibitors. Therefore, we determined if the pan-HDAC inhibitor vorinostat synergizes with fenretinide. We demonstrated cytotoxic synergy between vorinostat and fenretinide in nine TCLM cell lines at clinically achievable concentrations that lacked cytotoxicity for non-malignant cells (fibroblasts and blood mononuclear cells). In vivo , vorinostat + fenretinide + ketoconazole (enhances fenretinide exposures by inhibiting fenretinide metabolism) showed greater activity in subcutaneous TCLM xenograft models than other groups. Fenretinide + vorinostat increased reactive oxygen species (ROS, measured by 2′,7′-dichlorodihydrofluorescein diacetate dye), resulting in increased apoptosis (via transferase dUTP nick end labeling assay) and histone acetylation (by immunoblotting). The synergistic cytotoxicity, apoptosis, and histone acetylation of fenretinide + vorinostat was abrogated by the antioxidant vitamin C. Like romidepsin, vorinostat combined with fenretinide achieved synergistic cytotoxic activity and increased histone acetylation in preclinical models of TCLMs, but not in non-malignant cells. As vorinostat is an oral agent and not a P-glycoprotein substrate it may have advantages in such combination therapy. These data support conducting a clinical trial of vorinostat combined with fenretinide in relapsed and refractory TCLMs." @default.
• W3094483448 created "2020-10-29" @default.
• W3094483448 creator A5009524254 @default.
• W3094483448 creator A5025835928 @default.
• W3094483448 creator A5033274925 @default.
• W3094483448 creator A5035154881 @default.
• W3094483448 creator A5052335145 @default.
• W3094483448 creator A5058354009 @default.
• W3094483448 creator A5065828728 @default.
• W3094483448 creator A5072369293 @default.
• W3094483448 date "2020-10-19" @default.
• W3094483448 modified "2023-10-16" @default.
• W3094483448 title "Vorinostat and fenretinide synergize in preclinical models of T-cell lymphoid malignancies" @default.
• W3094483448 cites W1493289946 @default.
• W3094483448 cites W1591208477 @default.
• W3094483448 cites W1996105433 @default.
• W3094483448 cites W2006416369 @default.
• W3094483448 cites W2007239150 @default.
• W3094483448 cites W2014811174 @default.
• W3094483448 cites W2029820254 @default.
• W3094483448 cites W2060940529 @default.
• W3094483448 cites W2063124444 @default.
• W3094483448 cites W2070433411 @default.
• W3094483448 cites W2080029028 @default.
• W3094483448 cites W2084393474 @default.
• W3094483448 cites W2089230581 @default.
• W3094483448 cites W2096142215 @default.
• W3094483448 cites W2109496184 @default.
• W3094483448 cites W2110957729 @default.
• W3094483448 cites W2113219587 @default.
• W3094483448 cites W2114130971 @default.
• W3094483448 cites W2128352319 @default.
• W3094483448 cites W2135405268 @default.
• W3094483448 cites W2136448271 @default.
• W3094483448 cites W2139201146 @default.
• W3094483448 cites W2140587752 @default.
• W3094483448 cites W2143217083 @default.
• W3094483448 cites W2152966058 @default.
• W3094483448 cites W2160097566 @default.
• W3094483448 cites W2170103350 @default.
• W3094483448 cites W2171365282 @default.
• W3094483448 cites W2193255355 @default.
• W3094483448 cites W2271267346 @default.
• W3094483448 cites W2416844197 @default.
• W3094483448 cites W2484616545 @default.
• W3094483448 cites W2582533555 @default.
• W3094483448 cites W2603041370 @default.
• W3094483448 cites W2605715045 @default.
• W3094483448 cites W2724336500 @default.
• W3094483448 cites W2739831937 @default.
• W3094483448 cites W2892837162 @default.
• W3094483448 cites W2895230977 @default.
• W3094483448 cites W2901052143 @default.
• W3094483448 cites W2919761312 @default.
• W3094483448 cites W2971410229 @default.
• W3094483448 cites W2990311542 @default.
• W3094483448 cites W4313314629 @default.
• W3094483448 doi "https://doi.org/10.1097/cad.0000000000001008" @default.
• W3094483448 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33079733" @default.
• W3094483448 hasPublicationYear "2020" @default.
• W3094483448 type Work @default.
• W3094483448 sameAs 3094483448 @default.
• W3094483448 citedByCount "8" @default.
• W3094483448 countsByYear W30944834482020 @default.
• W3094483448 countsByYear W30944834482021 @default.
• W3094483448 countsByYear W30944834482022 @default.
• W3094483448 crossrefType "journal-article" @default.
• W3094483448 hasAuthorship W3094483448A5009524254 @default.
• W3094483448 hasAuthorship W3094483448A5025835928 @default.
• W3094483448 hasAuthorship W3094483448A5033274925 @default.
• W3094483448 hasAuthorship W3094483448A5035154881 @default.
• W3094483448 hasAuthorship W3094483448A5052335145 @default.
• W3094483448 hasAuthorship W3094483448A5058354009 @default.
• W3094483448 hasAuthorship W3094483448A5065828728 @default.
• W3094483448 hasAuthorship W3094483448A5072369293 @default.
• W3094483448 hasConcept C104317684 @default.
• W3094483448 hasConcept C109316439 @default.
• W3094483448 hasConcept C154317977 @default.
• W3094483448 hasConcept C168831097 @default.
• W3094483448 hasConcept C185592680 @default.
• W3094483448 hasConcept C190283241 @default.
• W3094483448 hasConcept C202751555 @default.
• W3094483448 hasConcept C2775954498 @default.
• W3094483448 hasConcept C2776202225 @default.
• W3094483448 hasConcept C2776262904 @default.
• W3094483448 hasConcept C2778305200 @default.
• W3094483448 hasConcept C2780533455 @default.
• W3094483448 hasConcept C2781121885 @default.
• W3094483448 hasConcept C2781462825 @default.
• W3094483448 hasConcept C502942594 @default.
• W3094483448 hasConcept C55493867 @default.
• W3094483448 hasConcept C64927066 @default.
• W3094483448 hasConcept C71924100 @default.
• W3094483448 hasConcept C98274493 @default.
• W3094483448 hasConceptScore W3094483448C104317684 @default.
• W3094483448 hasConceptScore W3094483448C109316439 @default.
• W3094483448 hasConceptScore W3094483448C154317977 @default.
• W3094483448 hasConceptScore W3094483448C168831097 @default.

• next