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• W3094496619 abstract "Systemic lupus erythematosus (SLE) is characterized by increased DNA demethylation in T cells, although it is unclear whether this occurs primarily in a subset of SLE T cells. The process driving the DNA demethylation and the consequences on overall gene expression are also poorly understood and whether this represents a secondary consequence of SLE or a primary contributing factor. Lupus-prone lpr mice accumulate large numbers of T cells with age because of a mutation in Fas (CD95). The accumulating T cells include an unusual population of CD4-CD8-TCR-αβ+ (DN) T cells that arise from CD8+ precursors and are also found in human SLE. We have previously observed that T cell accumulation in lpr mice is due to dysregulation of T cell homeostatic proliferation, which parallels an increased expression of numerous genes in the DN subset, including several proinflammatory molecules and checkpoint blockers. We thus determined the DNA methylome in lpr DN T cells compared with their CD8+ precursors. Our findings show that DN T cells manifest discrete sites of extensive demethylation throughout the genome, and these sites correspond to the location of a large proportion of the upregulated genes. Thus, dysregulated homeostatic proliferation in lpr mice and consequent epigenetic alterations may be a contributing factor to lupus pathogenesis." @default.
• W3094496619 created "2020-10-29" @default.
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• W3094496619 date "2020-10-01" @default.
• W3094496619 modified "2023-10-12" @default.
• W3094496619 title "Selective DNA Demethylation Accompanies T Cell Homeostatic Proliferation and Gene Regulation in Lupus-Prone <i>lpr</i> Mice" @default.
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• W3094496619 doi "https://doi.org/10.4049/immunohorizons.2000078" @default.
• W3094496619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8141279" @default.
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• W3094496619 hasPublicationYear "2020" @default.
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