FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094500133> ?p ?o ?g. }

• W3094500133 endingPage "713" @default.
• W3094500133 startingPage "702" @default.
• W3094500133 abstract "Altered alternative splicing (AS) events are considered pervasive causes that result in the development of carcinogenesis. Herein, we identified reprogrammed expression and splicing profiles of Muscle blind-like protein 1 (MBNL1) transcripts in tumorous tissues compared to those of adjacent normal tissues dissected from individual colorectal cancer (CRC) patients using whole-transcriptome analyses. MBNL1 transcript 8 (MBNL18) containing exons 5 and 7 was majorly generated by cancerous tissues and CRC-derived cell lines compared with those of the normal counterparts. Interplay between the exonic CA-rich element and upregulated SRSF3 facilitated the inclusion of MBNL1 exons 5 and 7, which encode a bipartite nuclear localization signal (NLS) and conformational NLS. Moreover, abundant SRSF3 interfered with the autoregulatory mechanism involved in utilization of MBNL1 exons 5 and 7, resulting in enrichment of the MBNL18 isoform in cultured CRC cell lines. Subsequently, an increase in the MBNL18 isoform drove a shift in the apoptotic chromatin condensation inducer in nucleus 1-S (Acin1-S) isoform to the Acin1-L isoform, leading to diminished DNA fragmentation in cultured CRC cells under oxidative stress. Taken together, SRSF3-MBNL1-Acin1 was demonstrated to constitute an emerging axis which is relevant to proapoptotic signatures and post-transcriptional events of CRC cells." @default.
• W3094500133 created "2020-10-29" @default.
• W3094500133 creator A5019853786 @default.
• W3094500133 creator A5020357559 @default.
• W3094500133 creator A5036761448 @default.
• W3094500133 creator A5040201107 @default.
• W3094500133 creator A5086565881 @default.
• W3094500133 creator A5089981324 @default.
• W3094500133 date "2020-12-01" @default.
• W3094500133 modified "2023-09-24" @default.
• W3094500133 title "The SRSF3-MBNL1-Acin1 circuit constitutes an emerging axis to lessen DNA fragmentation in colorectal cancer via an alternative splicing mechanism" @default.
• W3094500133 cites W1591022300 @default.
• W3094500133 cites W1965733051 @default.
• W3094500133 cites W1990507930 @default.
• W3094500133 cites W1991898382 @default.
• W3094500133 cites W1997919268 @default.
• W3094500133 cites W2009258895 @default.
• W3094500133 cites W2009888143 @default.
• W3094500133 cites W2010052786 @default.
• W3094500133 cites W2012768611 @default.
• W3094500133 cites W2018952308 @default.
• W3094500133 cites W2047795717 @default.
• W3094500133 cites W2063530272 @default.
• W3094500133 cites W2076791245 @default.
• W3094500133 cites W2090333731 @default.
• W3094500133 cites W2099399810 @default.
• W3094500133 cites W2108174762 @default.
• W3094500133 cites W2109731947 @default.
• W3094500133 cites W2112760828 @default.
• W3094500133 cites W2117922162 @default.
• W3094500133 cites W2123560621 @default.
• W3094500133 cites W2138679397 @default.
• W3094500133 cites W2147072570 @default.
• W3094500133 cites W2154480798 @default.
• W3094500133 cites W2163462267 @default.
• W3094500133 cites W2225699583 @default.
• W3094500133 cites W2281419701 @default.
• W3094500133 cites W2410306399 @default.
• W3094500133 cites W2473745815 @default.
• W3094500133 cites W2558889421 @default.
• W3094500133 cites W2592526216 @default.
• W3094500133 cites W2604296578 @default.
• W3094500133 cites W2611373388 @default.
• W3094500133 cites W2750771238 @default.
• W3094500133 cites W2760469823 @default.
• W3094500133 cites W2767420614 @default.
• W3094500133 cites W2789956212 @default.
• W3094500133 cites W2790576796 @default.
• W3094500133 cites W2809624163 @default.
• W3094500133 cites W2821094134 @default.
• W3094500133 cites W2886318879 @default.
• W3094500133 cites W2889104271 @default.
• W3094500133 cites W2889731549 @default.
• W3094500133 cites W2892297195 @default.
• W3094500133 cites W2901482817 @default.
• W3094500133 cites W2905350738 @default.
• W3094500133 cites W2951255673 @default.
• W3094500133 cites W2987476970 @default.
• W3094500133 cites W3016574632 @default.
• W3094500133 doi "https://doi.org/10.1016/j.neo.2020.10.002" @default.
• W3094500133 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7586066" @default.
• W3094500133 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33142236" @default.
• W3094500133 hasPublicationYear "2020" @default.
• W3094500133 type Work @default.
• W3094500133 sameAs 3094500133 @default.
• W3094500133 citedByCount "5" @default.
• W3094500133 countsByYear W30945001332021 @default.
• W3094500133 countsByYear W30945001332022 @default.
• W3094500133 countsByYear W30945001332023 @default.
• W3094500133 crossrefType "journal-article" @default.
• W3094500133 hasAuthorship W3094500133A5019853786 @default.
• W3094500133 hasAuthorship W3094500133A5020357559 @default.
• W3094500133 hasAuthorship W3094500133A5036761448 @default.
• W3094500133 hasAuthorship W3094500133A5040201107 @default.
• W3094500133 hasAuthorship W3094500133A5086565881 @default.
• W3094500133 hasAuthorship W3094500133A5089981324 @default.
• W3094500133 hasBestOaLocation W30945001331 @default.
• W3094500133 hasConcept C104317684 @default.
• W3094500133 hasConcept C121332964 @default.
• W3094500133 hasConcept C121608353 @default.
• W3094500133 hasConcept C18903297 @default.
• W3094500133 hasConcept C190283241 @default.
• W3094500133 hasConcept C191015642 @default.
• W3094500133 hasConcept C194583182 @default.
• W3094500133 hasConcept C31573885 @default.
• W3094500133 hasConcept C36823959 @default.
• W3094500133 hasConcept C43759708 @default.
• W3094500133 hasConcept C502942594 @default.
• W3094500133 hasConcept C526805850 @default.
• W3094500133 hasConcept C54355233 @default.
• W3094500133 hasConcept C54458228 @default.
• W3094500133 hasConcept C62520636 @default.
• W3094500133 hasConcept C67705224 @default.
• W3094500133 hasConcept C70721500 @default.
• W3094500133 hasConcept C71924100 @default.
• W3094500133 hasConcept C86803240 @default.
• W3094500133 hasConcept C89611455 @default.
• W3094500133 hasConceptScore W3094500133C104317684 @default.

• next