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- W3094530118 abstract "In this work, the development and testing of a novel fiber-optic based label-free biosensor is presented, whose performance were verified through the detection of C-reactive protein (CRP) in serum. The device is based on a long period grating fabricated in a double cladding fiber with a W-shaped refractive index (RI) profile. As a result, the working point of the device was tuned to the mode transition region by chemical etching of the outer fiber cladding, obtaining a significant enhancement of the RI sensitivity and an excellent visibility of the grating resonances due to the mode transition in an all-silica structure. The fiber transducer was coated with a nanometric thin layer of graphene oxide in order to provide functional groups for the covalent immobilization of the biological recognition element. A very low limit of detection of about 0.15 ng/mL was obtained during the detection of CRP in serum, and a large working range (1 ng/mL – 100 μg/mL) of clinical relevance has been also achieved." @default.
- W3094530118 created "2020-10-29" @default.
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- W3094530118 date "2021-01-01" @default.
- W3094530118 modified "2023-10-16" @default.
- W3094530118 title "Long period grating in double cladding fiber coated with graphene oxide as high-performance optical platform for biosensing" @default.
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- W3094530118 doi "https://doi.org/10.1016/j.bios.2020.112747" @default.
- W3094530118 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7581380" @default.
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