FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094530462> ?p ?o ?g. }

• W3094530462 endingPage "178" @default.
• W3094530462 startingPage "173" @default.
• W3094530462 abstract "To investigate the association between Apolipoprotein E (APOE) genotype and freezing of gait (FOG) in Parkinson's disease (PD).This cohort study included 339 early PD patients who were divided into APOE ε4-positive (n = 88) and ε4-negative (n = 251) groups. They were followed-up for up to 6 years to identify the development of FOG. To investigate the influence of CSF β-amyloid 1-42 (Aβ42) on the association between APOE ε4 and FOG, the patients were additionally dichotomized into high-level and low-level groups using three different cutoff values for the CSF Aβ42 levels.At baseline, the APOE ε4-positive group had lower CSF Aβ42 levels than the APOE ε4-negative group. During a median follow-up of 5.0 years, the APOE ε4-positive group had a higher incidence of FOG than the APOE ε4-negative group. In the multivariable Cox model excluding CSF Aβ42, APOE ε4 was a significant predictor of FOG. However, after adding CSF Aβ42 in the model, APOE ε4 did not survive, whereas lower CSF Aβ42 levels were associated with FOG. In the subgroup analyses, the effect of the APOE ε4 allele was not found in the low-level group. However, in the high-level group, the APOE ε4 allele independently increased the risk of FOG, and this association was stronger than the association with CSF Aβ42.The APOE ε4 allele may be a novel genetic risk factor for FOG in PD. This association seemed to be mainly mediated by Aβ-dependent pathways, but its Aβ-independent effects might also contribute to the development of FOG." @default.
• W3094530462 created "2020-10-29" @default.
• W3094530462 creator A5035047849 @default.
• W3094530462 creator A5056969461 @default.
• W3094530462 creator A5059131847 @default.
• W3094530462 creator A5074497662 @default.
• W3094530462 creator A5076649890 @default.
• W3094530462 date "2020-12-01" @default.
• W3094530462 modified "2023-10-02" @default.
• W3094530462 title "Apolipoprotein E ε4 genotype and risk of freezing of gait in Parkinson's disease" @default.
• W3094530462 cites W1591882542 @default.
• W3094530462 cites W1887821162 @default.
• W3094530462 cites W1922746862 @default.
• W3094530462 cites W2006858320 @default.
• W3094530462 cites W2033023107 @default.
• W3094530462 cites W2040546047 @default.
• W3094530462 cites W2063024868 @default.
• W3094530462 cites W2108572733 @default.
• W3094530462 cites W2110626075 @default.
• W3094530462 cites W2127558621 @default.
• W3094530462 cites W2129497119 @default.
• W3094530462 cites W2135072527 @default.
• W3094530462 cites W2148161188 @default.
• W3094530462 cites W2159552567 @default.
• W3094530462 cites W2729228393 @default.
• W3094530462 cites W2744298518 @default.
• W3094530462 cites W2761168960 @default.
• W3094530462 cites W2770769270 @default.
• W3094530462 cites W2791829813 @default.
• W3094530462 cites W2796381877 @default.
• W3094530462 cites W2809941443 @default.
• W3094530462 cites W2889106553 @default.
• W3094530462 cites W2898850833 @default.
• W3094530462 cites W2902897479 @default.
• W3094530462 cites W2915211532 @default.
• W3094530462 cites W2965401191 @default.
• W3094530462 cites W2983218174 @default.
• W3094530462 cites W3004824376 @default.
• W3094530462 cites W3004888206 @default.
• W3094530462 doi "https://doi.org/10.1016/j.parkreldis.2020.10.033" @default.
• W3094530462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33161290" @default.
• W3094530462 hasPublicationYear "2020" @default.
• W3094530462 type Work @default.
• W3094530462 sameAs 3094530462 @default.
• W3094530462 citedByCount "10" @default.
• W3094530462 countsByYear W30945304622021 @default.
• W3094530462 countsByYear W30945304622022 @default.
• W3094530462 countsByYear W30945304622023 @default.
• W3094530462 crossrefType "journal-article" @default.
• W3094530462 hasAuthorship W3094530462A5035047849 @default.
• W3094530462 hasAuthorship W3094530462A5056969461 @default.
• W3094530462 hasAuthorship W3094530462A5059131847 @default.
• W3094530462 hasAuthorship W3094530462A5074497662 @default.
• W3094530462 hasAuthorship W3094530462A5076649890 @default.
• W3094530462 hasConcept C104317684 @default.
• W3094530462 hasConcept C120665830 @default.
• W3094530462 hasConcept C121332964 @default.
• W3094530462 hasConcept C126322002 @default.
• W3094530462 hasConcept C134018914 @default.
• W3094530462 hasConcept C135763542 @default.
• W3094530462 hasConcept C180754005 @default.
• W3094530462 hasConcept C2779134260 @default.
• W3094530462 hasConcept C2779734285 @default.
• W3094530462 hasConcept C50440223 @default.
• W3094530462 hasConcept C54355233 @default.
• W3094530462 hasConcept C57089818 @default.
• W3094530462 hasConcept C61511704 @default.
• W3094530462 hasConcept C71924100 @default.
• W3094530462 hasConcept C86803240 @default.
• W3094530462 hasConcept C90924648 @default.
• W3094530462 hasConceptScore W3094530462C104317684 @default.
• W3094530462 hasConceptScore W3094530462C120665830 @default.
• W3094530462 hasConceptScore W3094530462C121332964 @default.
• W3094530462 hasConceptScore W3094530462C126322002 @default.
• W3094530462 hasConceptScore W3094530462C134018914 @default.
• W3094530462 hasConceptScore W3094530462C135763542 @default.
• W3094530462 hasConceptScore W3094530462C180754005 @default.
• W3094530462 hasConceptScore W3094530462C2779134260 @default.
• W3094530462 hasConceptScore W3094530462C2779734285 @default.
• W3094530462 hasConceptScore W3094530462C50440223 @default.
• W3094530462 hasConceptScore W3094530462C54355233 @default.
• W3094530462 hasConceptScore W3094530462C57089818 @default.
• W3094530462 hasConceptScore W3094530462C61511704 @default.
• W3094530462 hasConceptScore W3094530462C71924100 @default.
• W3094530462 hasConceptScore W3094530462C86803240 @default.
• W3094530462 hasConceptScore W3094530462C90924648 @default.
• W3094530462 hasLocation W30945304621 @default.
• W3094530462 hasLocation W30945304622 @default.
• W3094530462 hasOpenAccess W3094530462 @default.
• W3094530462 hasPrimaryLocation W30945304621 @default.
• W3094530462 hasRelatedWork W2068963435 @default.
• W3094530462 hasRelatedWork W2094823974 @default.
• W3094530462 hasRelatedWork W2136769627 @default.
• W3094530462 hasRelatedWork W2150522638 @default.
• W3094530462 hasRelatedWork W2160510592 @default.
• W3094530462 hasRelatedWork W2275976839 @default.
• W3094530462 hasRelatedWork W2355380693 @default.
• W3094530462 hasRelatedWork W2375419527 @default.

• next