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• W3094544582 abstract "To explore how brain radiation (RT) may affect fine motor coordination, we prospectively investigated the association between imaging biomarkers of cortical and white matter (WM) injury to motor regions of interest (ROIs) and longitudinal fine motor coordination among primary brain tumor patients. On a prospective trial, 57 primary brain tumor patients undergoing fractionated brain RT underwent brain MRI, diffusion tensor imaging, and fine motor assessments (Delis-Kaplan Executive Function System Trail Making Test Motor Speed [DKEFS-MS], Grooved Pegboard Dominant Hand [PDH], and Grooved Pegboard Nondominant Hand [PNDH]) at baseline and 3, 6, and 12 months post-RT. Reliable change indices (RCI-PE) between 0 and 6 months measured change in function; one-sample t-tests evaluated significant change. Left- and right-sided sensorimotor cortices and superficial WM, corticospinal tracts, cerebellar cortices and WM, and basal ganglia (caudate, putamen, pallidum) were autosegmented. Tumor, surgical bed, and edema were censored to avoid confounding. Cortical thickness, WM volume, and diffusion biomarkers (FA and MD) were measured within each ROI. Increase in MD and decrease in FA indicate WM injury. Linear mixed-effects models assessed biomarkers as longitudinal predictors of motor scores, controlling for time and subject-specific effects. P-values were corrected for multiple comparisons. Most (86%) patients were right-handed and 32% had frontal tumors. There was no significant group change in motor coordination between 0 and 6 months. Motor coordination declined among older patients (DKEFS-MS p = 0.001) and non-white patients (PNDH p = 0.02) and improved among patients taking antiepileptic drugs (PDH p = 0.049). Higher RT dose correlated with increased MD in the right precentral WM (p = 0.047) and thinning in the right paracentral cortex (p = 0.025). Atrophy within the left and right cerebellar cortex was associated with worse performance on PDH (L: p = 0.042; R: p = 0.042) and PNDH (L: p = 0.007; R: p = 0.007). Reduced FA in the left precentral WM correlated with worse DKEFS-MS scores (p = 0.043). Increased MD in the left (p = 0.043) and right (p = 0.016) cerebellar WM was associated with poorer DKEFS-MS scores, while higher MD in the left corona radiata predicted for worse PNDH scores (p < 0.001). Finally, thinning of the left and right precentral cortex was associated with decreased DKEFS-MS (L: p = 0.015; R: p = 0.028) and PDH (L: p = 0.028; R: p = 0.032) performance. Motor coordination declined among older patients and non-white patients and improved among patients taking antiepileptic drugs. Biomarkers of microstructural injury in motor-associated brain structures predicted for worse motor coordination, in both dominant and non-dominant hands, after RT. These regions represent possibilities for dose avoidance to preserve motor coordination." @default.
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• W3094544582 date "2020-11-01" @default.
• W3094544582 modified "2023-10-16" @default.
• W3094544582 title "Quantitative Imaging Biomarkers Associated With Fine Motor Coordination After Brain Radiotherapy (RT)" @default.
• W3094544582 doi "https://doi.org/10.1016/j.ijrobp.2020.07.144" @default.
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