FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094559280> ?p ?o ?g. }

• W3094559280 endingPage "e0240880" @default.
• W3094559280 startingPage "e0240880" @default.
• W3094559280 abstract "Background There is very little data on long-term immune recovery responses in patients on suppressive antiretroviral therapy (ART) in the setting of sub-Saharan Africa (SSA). Thus, we sought to determine CD4+ T-cell, CD8+ T-cell and CD4/CD8 ratio responses in a cohort of HIV infected individuals on sustained suppressive ART followed up for more than a decade. Methods The cohort comprised adult patients who started ART between 2001 and 2007 and followed for up to 14 years. Trends in median CD4+ T-cells, CD8+ T-cells and CD4/CD8 ratio were reviewed retrospectively. Poisson regression models were used to identify factors associated with achieving normalized T-cell biomarkers. Kaplan-Meier curves were used to estimate the probability of attaining normalized counts while on suppressive ART. Results A total of 227 patients with a median duration of follow-up on ART of 12 (IQR: 10.5–13.0) years were included. CD4 cell count increased from baseline median of 138 cells (IQR: 70–202) to 555 cells (IQR: 417–830). CD4 cell increased continuously up until 5 years, after which it plateaued up until 14 years of follow up. Only 69.6% normalized their CD4 cell count within a median of 6.5 (IQR: 3.0–10.5) years. In addition, only 15.9% of the cohort were able to achieve the median reference CD4+ T-cell threshold count in Ethiopians (≈760 cells/μL). CD8+ T-cell counts increased initially until year 1, after which continuous decrease was ascertained. CD4/CD8 ratio trend revealed continuous increase throughout the course of ART, and increased from a median baseline of 0.14 (IQR: 0.09–0.22) to a median of 0.70 (IQR: 0.42–0.95). However, only 12.3% normalized their ratio (≥ 1.0) after a median of 11.5 years. In addition, only 8.8% of the cohort were able to achieve the median reference ratio of healthy Ethiopians. Conclusion Determination of both CD4+ and CD8+ T-cells, along with CD4/CD8 ratio is highly relevant in long-term follow-up of patients to assess immune recovery. Monitoring ratio levels may serve as a better biomarker risk for disease progression among patients on long-term ART. In addition, the findings emphasize the relevance of initiation of ART at the early stage of HIV-1 infection." @default.
• W3094559280 created "2020-10-29" @default.
• W3094559280 creator A5032303695 @default.
• W3094559280 creator A5044548677 @default.
• W3094559280 creator A5050838527 @default.
• W3094559280 creator A5057212485 @default.
• W3094559280 creator A5074990921 @default.
• W3094559280 creator A5011839201 @default.
• W3094559280 date "2020-10-22" @default.
• W3094559280 modified "2023-10-17" @default.
• W3094559280 title "Immune recovery in HIV-1 infected patients with sustained viral suppression under long-term antiretroviral therapy in Ethiopia" @default.
• W3094559280 cites W1488316909 @default.
• W3094559280 cites W1972585165 @default.
• W3094559280 cites W1978759399 @default.
• W3094559280 cites W1991449638 @default.
• W3094559280 cites W1994593060 @default.
• W3094559280 cites W1998353416 @default.
• W3094559280 cites W2001017566 @default.
• W3094559280 cites W2003071165 @default.
• W3094559280 cites W2005006791 @default.
• W3094559280 cites W2033406568 @default.
• W3094559280 cites W2034321374 @default.
• W3094559280 cites W2039197138 @default.
• W3094559280 cites W2039777415 @default.
• W3094559280 cites W2053252472 @default.
• W3094559280 cites W2055241434 @default.
• W3094559280 cites W2065148379 @default.
• W3094559280 cites W2067989686 @default.
• W3094559280 cites W2072122526 @default.
• W3094559280 cites W2074218153 @default.
• W3094559280 cites W2078262030 @default.
• W3094559280 cites W2100903133 @default.
• W3094559280 cites W2101135575 @default.
• W3094559280 cites W2106164053 @default.
• W3094559280 cites W2112531370 @default.
• W3094559280 cites W2120293408 @default.
• W3094559280 cites W2122932058 @default.
• W3094559280 cites W2132826589 @default.
• W3094559280 cites W2140573695 @default.
• W3094559280 cites W2140606947 @default.
• W3094559280 cites W2140693353 @default.
• W3094559280 cites W2144188479 @default.
• W3094559280 cites W2151362414 @default.
• W3094559280 cites W2154729256 @default.
• W3094559280 cites W2155653612 @default.
• W3094559280 cites W2165955491 @default.
• W3094559280 cites W2167354451 @default.
• W3094559280 cites W2169319632 @default.
• W3094559280 cites W2172274075 @default.
• W3094559280 cites W2195991516 @default.
• W3094559280 cites W2281358660 @default.
• W3094559280 cites W2298488851 @default.
• W3094559280 cites W2314194694 @default.
• W3094559280 cites W2337523304 @default.
• W3094559280 cites W2534110833 @default.
• W3094559280 cites W2597663489 @default.
• W3094559280 cites W2736082768 @default.
• W3094559280 cites W2789522385 @default.
• W3094559280 cites W2790526544 @default.
• W3094559280 cites W2945677951 @default.
• W3094559280 cites W3028154672 @default.
• W3094559280 doi "https://doi.org/10.1371/journal.pone.0240880" @default.
• W3094559280 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7580989" @default.
• W3094559280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33091053" @default.
• W3094559280 hasPublicationYear "2020" @default.
• W3094559280 type Work @default.
• W3094559280 sameAs 3094559280 @default.
• W3094559280 citedByCount "8" @default.
• W3094559280 countsByYear W30945592802021 @default.
• W3094559280 countsByYear W30945592802022 @default.
• W3094559280 countsByYear W30945592802023 @default.
• W3094559280 crossrefType "journal-article" @default.
• W3094559280 hasAuthorship W3094559280A5011839201 @default.
• W3094559280 hasAuthorship W3094559280A5032303695 @default.
• W3094559280 hasAuthorship W3094559280A5044548677 @default.
• W3094559280 hasAuthorship W3094559280A5050838527 @default.
• W3094559280 hasAuthorship W3094559280A5057212485 @default.
• W3094559280 hasAuthorship W3094559280A5074990921 @default.
• W3094559280 hasBestOaLocation W30945592801 @default.
• W3094559280 hasConcept C126322002 @default.
• W3094559280 hasConcept C142462285 @default.
• W3094559280 hasConcept C167135981 @default.
• W3094559280 hasConcept C167672396 @default.
• W3094559280 hasConcept C201903717 @default.
• W3094559280 hasConcept C203014093 @default.
• W3094559280 hasConcept C2776090121 @default.
• W3094559280 hasConcept C2908647359 @default.
• W3094559280 hasConcept C2909287720 @default.
• W3094559280 hasConcept C2993143319 @default.
• W3094559280 hasConcept C3013748606 @default.
• W3094559280 hasConcept C3020391436 @default.
• W3094559280 hasConcept C71924100 @default.
• W3094559280 hasConcept C72563966 @default.
• W3094559280 hasConcept C73269764 @default.
• W3094559280 hasConcept C8891405 @default.
• W3094559280 hasConcept C90924648 @default.
• W3094559280 hasConcept C99454951 @default.
• W3094559280 hasConceptScore W3094559280C126322002 @default.

• next