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• W3094560913 abstract "Absorbed dose to red marrow (Drm) can be calculated using blood dosimetry. However, this method is laborious and invasive. Therefore, image-based dosimetry is the method of choice. Nonetheless, the commercial software is expensive. The goal of this work was to develop a simplified excel spreadsheet for image-based radioiodine red marrow dosimetry.The serial whole-body images (acquired at 2nd, 6th, 24th, 48th, and 72th hours) of 29 patients from the routine pretherapeutic dosimetry protocol were retrospectively reanalyzed. The commercial OLINDA/EXM image-based dosimetry software was used to calculate the whole-body time-integrated activity coefficient (TIACWB) and Drm [in terms of absorbed dose coefficient (drm)]. For the simplified excel spreadsheet, the wholebody count was obtained from the vendor-supplied software. Then, the TIACWB was computed by a fitting time-activity curve using an Excel function. S factor was taken from other publications and scaled according to the patient-specific mass. A comparison of the TIACWB and drm from both methods was done using a non-inferiority test using a paired t-test or the Wilcoxon signed-rank test.The TIACWB showed no significant difference between both methods (p=0.243). The calculated Drm from a simplified Excel spreadsheet was assumed to be statistically non-inferior to the commercial OLINDA/EXM image-based dosimetry software with the non-inferiority margin of 0.02 (p<0.05).The dose assessment from a simplified Excel spreadsheet is feasible and relatively low cost compared to the commercial OLINDA/EXM image-based dosimetry software.Kırmızı iliğin absorbe ettiği doz (Drm) kan dozimetresi kullanılarak hesaplanabilir. Ancak tam kan yöntemi zahmetli ve invaziftir. Bu nedenle, görüntü bazlı dozimetri tercih edilen yöntemdir. Bununla birlikte, ticari yazılım pahalıdır. Bu çalışmanın amacı, görüntü tabanlı radyoiyot kırmızı ilik dozimetrisi için basitleştirilmiş bir excel elektronik tablosu geliştirmektir.Yirmi dokuz hastanın rutin tedavi öncesi dozimetri protokolündeki seri tüm vücut görüntüleri (2, 6, 24, 48 ve 72. saatlerde elde edilen) retrospektif olarak yeniden analiz edilmiştir. Rutin olarak, ticari OLINDA/EXM görüntü tabanlı dozimetri yazılımı, tüm vücut zamana entegre edilmiş aktivite katsayısı (TIACWB) ve Drm [absorbe edilen doz katsayısı (drm)] hesabı için kullanıldı. Basitleştirilmiş bir Excel elektronik tablosu için, tüm vücut sayısı satıcı tarafından sağlanan yazılımdan elde edilmiştir. Daha sonra TIACWB, Excel işlevi kullanılarak oluşturulan zaman-aktivite eğrisi ile hesaplandı. S faktörü diğer yayınlardan alınarak hastaya özel kitleye göre ölçeklendirildi. İki yöntem ile elde edilen TIACWB ve drm değerlerinin karşılaştırması, bağımlı örneklem t-testi veya Wilcoxon işaretli sıralar testine dayalı bir non-inferiority test kullanılarak analiz edildi.TIACWB iki yöntem arasında anlamlı bir fark göstermedi (eşleştirilmiş örneklem t-testi ile p değeri 0,243). Basitleştirilmiş bir Excel elektronik tablosundan hesaplanan drm değerinin, 0,02’lik non-inferiority payı ile ticari OLINDA/EXM görüntü tabanlı dozimetri yazılımı ile hesaplanan değerden istatistiksel olarak non-inferior olduğu görülmüştür (Wilcoxon işaretli sıralar testi ile p değeri <0,05).Basitleştirilmiş bir Excel elektronik tablosundan doz değerlendirmesi yapılabilir ve ticari OLINDA/EXM görüntü tabanlı dozimetri yazılımına kıyasla nispeten düşük maliyetlidir." @default.
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• W3094560913 date "2020-10-01" @default.
• W3094560913 modified "2023-10-14" @default.
• W3094560913 title "Red Marrow Absorbed Dose Calculation in Thyroid Cancer Patient Using a Simplified Excel Spreadsheet" @default.
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• W3094560913 doi "https://doi.org/10.4274/mirt.galenos.2020.71473" @default.
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