FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094570077> ?p ?o ?g. }

• W3094570077 endingPage "e549" @default.
• W3094570077 startingPage "e548" @default.
• W3094570077 abstract "Radiotherapy (RT) is one of the main approaches for treatment of lung cancer. A large number of preclinical and several clinical studies revealed that RT can activate the host’s anti-tumor immune system and induce abscopal effect. However, the optimal timing and its underlying mechanism of the combination of RT and immune checkpoint inhibitor (CHI) are unclear. MC38 cells were used for subcutaneous tumor formation in the left lower limbs (irradiation field) and the right lower limbs (non-irradiation field) of six-eight weeks old male C57BL/6 mice. When the tumor volume reached 150mm3, the mice were randomly assigned to receive RT (8Gy × 3F) with concurrent anti-PD-1 monoclonal antibody (mAb) or RT with sequential (1 week after the first irradiation) anti-PD-1 mAb (group B). The changes of immune microenvironment in irradiated and non-irradiated tumors in the two groups were analyzed by flow cytometry. Both RT with concurrent anti-PD-1 mAb and RT with sequential anti-PD-1 mAb could inhibit the growth of tumors in non-irradiation field. The number of CD4+T cells (CD45+CD44+CD4+T) and effector CD4+T cells (CD44+CD4+IFNγ + T) in non-irradiated tumors in the sequential group was significantly higher than that in the concurrent group, but which showed no significant difference between the two groups in irradiated tumors. Interestingly, CD8+T cells (CD45+CD44+CD8+T) and effector CD8+T cells (CD44+CD8+IFNγ + T) increased both in the irradiation and non-irradiation field in the sequential group compared with that in the concurrent group, while tumor associated macrophages (TAM, F4/80+CD11b+) and Treg cells (CD4+FoxP3+) in the sequential group decreased significantly. RT with sequential anti-PD-1 mAb reduced more exhausted CD8+T cells (PD-1+Eomes+of CD8+T) and induced more reinvigoration of exhausted T cell (Ki-67+PD-1+Emoes+CD8+T). The decrease of MDSCs (Gr1+CD11b+) in the non-irradiated tumors was observed in both groups, but there was no difference in the extent of this decrease between two groups. Compared with the concurrent combination, RT with sequential anti-PD-1 mAb is more effective in promoting the inflammatory tumor microenvironment in out-field tumors and inducing the abscopal effect, which provides a new perspective for further exploring the mechanism of optimal timing of combination. Funding: 81972853, 81572279, 2016J004, LC2019ZD009, 2018CR033." @default.
• W3094570077 created "2020-10-29" @default.
• W3094570077 creator A5022694667 @default.
• W3094570077 creator A5072855352 @default.
• W3094570077 date "2020-11-01" @default.
• W3094570077 modified "2023-10-14" @default.
• W3094570077 title "Radiotherapy With Sequential Αnti-PD-1 mAb Compared With Concurrent Αnti-PD-1 mAb Is Better In Enhancing The Abscopal Effect By Promoting The Inflammatory Tumor Microenvironment" @default.
• W3094570077 doi "https://doi.org/10.1016/j.ijrobp.2020.07.1706" @default.
• W3094570077 hasPublicationYear "2020" @default.
• W3094570077 type Work @default.
• W3094570077 sameAs 3094570077 @default.
• W3094570077 citedByCount "0" @default.
• W3094570077 crossrefType "journal-article" @default.
• W3094570077 hasAuthorship W3094570077A5022694667 @default.
• W3094570077 hasAuthorship W3094570077A5072855352 @default.
• W3094570077 hasBestOaLocation W30945700771 @default.
• W3094570077 hasConcept C1491633281 @default.
• W3094570077 hasConcept C159654299 @default.
• W3094570077 hasConcept C167672396 @default.
• W3094570077 hasConcept C203014093 @default.
• W3094570077 hasConcept C2776090121 @default.
• W3094570077 hasConcept C2776107976 @default.
• W3094570077 hasConcept C2780932548 @default.
• W3094570077 hasConcept C502942594 @default.
• W3094570077 hasConcept C542903549 @default.
• W3094570077 hasConcept C54355233 @default.
• W3094570077 hasConcept C553184892 @default.
• W3094570077 hasConcept C71924100 @default.
• W3094570077 hasConcept C86803240 @default.
• W3094570077 hasConcept C8891405 @default.
• W3094570077 hasConceptScore W3094570077C1491633281 @default.
• W3094570077 hasConceptScore W3094570077C159654299 @default.
• W3094570077 hasConceptScore W3094570077C167672396 @default.
• W3094570077 hasConceptScore W3094570077C203014093 @default.
• W3094570077 hasConceptScore W3094570077C2776090121 @default.
• W3094570077 hasConceptScore W3094570077C2776107976 @default.
• W3094570077 hasConceptScore W3094570077C2780932548 @default.
• W3094570077 hasConceptScore W3094570077C502942594 @default.
• W3094570077 hasConceptScore W3094570077C542903549 @default.
• W3094570077 hasConceptScore W3094570077C54355233 @default.
• W3094570077 hasConceptScore W3094570077C553184892 @default.
• W3094570077 hasConceptScore W3094570077C71924100 @default.
• W3094570077 hasConceptScore W3094570077C86803240 @default.
• W3094570077 hasConceptScore W3094570077C8891405 @default.
• W3094570077 hasIssue "3" @default.
• W3094570077 hasLocation W30945700771 @default.
• W3094570077 hasOpenAccess W3094570077 @default.
• W3094570077 hasPrimaryLocation W30945700771 @default.
• W3094570077 hasRelatedWork W1572283981 @default.
• W3094570077 hasRelatedWork W1984792059 @default.
• W3094570077 hasRelatedWork W2087041936 @default.
• W3094570077 hasRelatedWork W2087083440 @default.
• W3094570077 hasRelatedWork W2094194110 @default.
• W3094570077 hasRelatedWork W2170059847 @default.
• W3094570077 hasRelatedWork W3048051248 @default.
• W3094570077 hasRelatedWork W4313825888 @default.
• W3094570077 hasRelatedWork W4366256944 @default.
• W3094570077 hasRelatedWork W4376630897 @default.
• W3094570077 hasVolume "108" @default.
• W3094570077 isParatext "false" @default.
• W3094570077 isRetracted "false" @default.
• W3094570077 magId "3094570077" @default.
• W3094570077 workType "article" @default.