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- W3094577840 endingPage "97" @default.
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- W3094577840 abstract "Paroxysmal movement disorders mostly comprise paroxysmal dyskinesia and episodic ataxia, and can be the consequence of a genetic disorder or symptomatic of an acquired disease.In this review, the authors focused on certain hot-topic issues in the field: the respective contribution of the cerebellum and striatum to the generation of paroxysmal dyskinesia, the importance of striatal cAMP turnover in the pathogenesis of paroxysmal dyskinesia, the treatable causes of paroxysmal movement disorders not to be missed, with a special emphasis on the treatment strategy to bypass the glucose transport defect in paroxysmal movement disorders due to GLUT1 deficiency, and functional paroxysmal movement disorders.Treatment of genetic causes of paroxysmal movement disorders is evolving towards precision medicine with targeted gene-specific therapy. Alteration of the cerebellar output and modulation of the striatal cAMP turnover offer new perspectives for experimental therapeutics, at least for paroxysmal movement disorders due to selected causes. Further characterization of cell-specific molecular pathways or network dysfunctions that are critically involved in the pathogenesis of paroxysmal movement disorders will likely result in the identification of new biomarkers and testing of innovative-targeted therapeutics." @default.
- W3094577840 created "2020-10-29" @default.
- W3094577840 creator A5018190334 @default.
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- W3094577840 creator A5068151393 @default.
- W3094577840 creator A5074102862 @default.
- W3094577840 creator A5074748735 @default.
- W3094577840 date "2020-11-08" @default.
- W3094577840 modified "2023-10-17" @default.
- W3094577840 title "Current challenges in the pathophysiology, diagnosis, and treatment of paroxysmal movement disorders" @default.
- W3094577840 cites W1506219947 @default.
- W3094577840 cites W1544433045 @default.
- W3094577840 cites W1595740223 @default.
- W3094577840 cites W1803628705 @default.
- W3094577840 cites W1864885326 @default.
- W3094577840 cites W1904392094 @default.
- W3094577840 cites W1905244003 @default.
- W3094577840 cites W1909814622 @default.
- W3094577840 cites W1911782737 @default.
- W3094577840 cites W1914122617 @default.
- W3094577840 cites W1964268435 @default.
- W3094577840 cites W1965030220 @default.
- W3094577840 cites W1967763783 @default.
- W3094577840 cites W1970482417 @default.
- W3094577840 cites W1970956117 @default.
- W3094577840 cites W1973335238 @default.
- W3094577840 cites W1974790023 @default.
- W3094577840 cites W1979706691 @default.
- W3094577840 cites W1984008642 @default.
- W3094577840 cites W1986320574 @default.
- W3094577840 cites W1989301998 @default.
- W3094577840 cites W1989327482 @default.
- W3094577840 cites W1989932177 @default.
- W3094577840 cites W1993912666 @default.
- W3094577840 cites W2000656893 @default.
- W3094577840 cites W2003685579 @default.
- W3094577840 cites W2005269174 @default.
- W3094577840 cites W2006372829 @default.
- W3094577840 cites W2009397705 @default.
- W3094577840 cites W2010226885 @default.
- W3094577840 cites W2013605395 @default.
- W3094577840 cites W2015447367 @default.
- W3094577840 cites W2025776630 @default.
- W3094577840 cites W2027696747 @default.
- W3094577840 cites W2034395914 @default.
- W3094577840 cites W2035286056 @default.
- W3094577840 cites W2037384627 @default.
- W3094577840 cites W2038862551 @default.
- W3094577840 cites W2039307135 @default.
- W3094577840 cites W2039472685 @default.
- W3094577840 cites W2043673888 @default.
- W3094577840 cites W2045340497 @default.
- W3094577840 cites W2045791082 @default.
- W3094577840 cites W2047108643 @default.
- W3094577840 cites W2048377617 @default.
- W3094577840 cites W2052786669 @default.
- W3094577840 cites W2052887259 @default.
- W3094577840 cites W2055042909 @default.
- W3094577840 cites W2055751008 @default.
- W3094577840 cites W2060999194 @default.
- W3094577840 cites W2066052906 @default.
- W3094577840 cites W2069682040 @default.
- W3094577840 cites W2070393599 @default.
- W3094577840 cites W2072063864 @default.
- W3094577840 cites W2074142727 @default.
- W3094577840 cites W2075742505 @default.
- W3094577840 cites W2083059817 @default.
- W3094577840 cites W2084462975 @default.
- W3094577840 cites W2084950557 @default.
- W3094577840 cites W2086401423 @default.
- W3094577840 cites W2090105299 @default.
- W3094577840 cites W2092471003 @default.
- W3094577840 cites W2097339523 @default.
- W3094577840 cites W2098910453 @default.
- W3094577840 cites W2106334429 @default.
- W3094577840 cites W2108964834 @default.
- W3094577840 cites W2109209155 @default.
- W3094577840 cites W2110051711 @default.
- W3094577840 cites W2112215838 @default.
- W3094577840 cites W2112867302 @default.
- W3094577840 cites W2114940906 @default.
- W3094577840 cites W2118612570 @default.
- W3094577840 cites W2119450744 @default.
- W3094577840 cites W2120090642 @default.
- W3094577840 cites W2122476338 @default.
- W3094577840 cites W2127870946 @default.
- W3094577840 cites W2130672067 @default.
- W3094577840 cites W2134057323 @default.
- W3094577840 cites W2134583249 @default.
- W3094577840 cites W2134842890 @default.
- W3094577840 cites W2136541816 @default.
- W3094577840 cites W2150229917 @default.
- W3094577840 cites W2150379993 @default.
- W3094577840 cites W2153700031 @default.
- W3094577840 cites W2153704590 @default.
- W3094577840 cites W2157844154 @default.
- W3094577840 cites W2160988431 @default.