FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094584865> ?p ?o ?g. }

• W3094584865 endingPage "928" @default.
• W3094584865 startingPage "920" @default.
• W3094584865 abstract "The study of depression in humans depends on animal models that attempt to mimic specific features of the human syndrome. Most studies focus on one or a few behavioral domains, with time and practical considerations prohibiting a comprehensive evaluation. Although machine learning has enabled unbiased analysis of behavior in animals, this has not yet been applied to animal models of psychiatric disease.We performed chronic social defeat stress (CSDS) in mice and evaluated behavior with PsychoGenics' SmartCube, a high-throughput unbiased automated phenotyping platform that collects >2000 behavioral features based on machine learning. We evaluated group differences at several times post-CSDS and after administration of the antidepressant medication imipramine.SmartCube analysis after CSDS successfully separated control and defeated-susceptible mice, and defeated-resilient mice more resembled control mice. We observed a potentiation of CSDS effects over time. Treatment of susceptible mice with imipramine induced a 40.2% recovery of the defeated-susceptible phenotype as assessed by SmartCube.High-throughput analysis can simultaneously evaluate multiple behavioral alterations in an animal model for the study of depression, which provides a more unbiased and holistic approach to evaluating group differences after CSDS and perhaps can be applied to other mouse models of psychiatric disease." @default.
• W3094584865 created "2020-10-29" @default.
• W3094584865 creator A5049993782 @default.
• W3094584865 creator A5053771434 @default.
• W3094584865 creator A5057141960 @default.
• W3094584865 creator A5075531666 @default.
• W3094584865 creator A5075983414 @default.
• W3094584865 creator A5084900431 @default.
• W3094584865 creator A5089427847 @default.
• W3094584865 date "2021-05-01" @default.
• W3094584865 modified "2023-10-14" @default.
• W3094584865 title "Computational Analysis of Multidimensional Behavioral Alterations After Chronic Social Defeat Stress" @default.
• W3094584865 cites W1967437665 @default.
• W3094584865 cites W1977593923 @default.
• W3094584865 cites W1981654563 @default.
• W3094584865 cites W1990694352 @default.
• W3094584865 cites W2001930926 @default.
• W3094584865 cites W2007816528 @default.
• W3094584865 cites W2013598219 @default.
• W3094584865 cites W2024861481 @default.
• W3094584865 cites W2025500109 @default.
• W3094584865 cites W2042287782 @default.
• W3094584865 cites W2052183476 @default.
• W3094584865 cites W2052639257 @default.
• W3094584865 cites W2053489614 @default.
• W3094584865 cites W2064804693 @default.
• W3094584865 cites W2068289911 @default.
• W3094584865 cites W2073658789 @default.
• W3094584865 cites W2084145610 @default.
• W3094584865 cites W2087978290 @default.
• W3094584865 cites W2089770153 @default.
• W3094584865 cites W2111038577 @default.
• W3094584865 cites W2137920275 @default.
• W3094584865 cites W2164104699 @default.
• W3094584865 cites W2269289848 @default.
• W3094584865 cites W2314624240 @default.
• W3094584865 cites W2353111961 @default.
• W3094584865 cites W2430804118 @default.
• W3094584865 cites W2537624101 @default.
• W3094584865 cites W2557506570 @default.
• W3094584865 cites W2560565629 @default.
• W3094584865 cites W2619718464 @default.
• W3094584865 cites W2626018769 @default.
• W3094584865 cites W2765193380 @default.
• W3094584865 cites W2865698779 @default.
• W3094584865 cites W2887114371 @default.
• W3094584865 cites W2892779178 @default.
• W3094584865 cites W2943374329 @default.
• W3094584865 cites W2969495394 @default.
• W3094584865 cites W2978956383 @default.
• W3094584865 cites W3002198638 @default.
• W3094584865 doi "https://doi.org/10.1016/j.biopsych.2020.10.010" @default.
• W3094584865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8052271" @default.
• W3094584865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33309017" @default.
• W3094584865 hasPublicationYear "2021" @default.
• W3094584865 type Work @default.
• W3094584865 sameAs 3094584865 @default.
• W3094584865 citedByCount "12" @default.
• W3094584865 countsByYear W30945848652020 @default.
• W3094584865 countsByYear W30945848652021 @default.
• W3094584865 countsByYear W30945848652022 @default.
• W3094584865 countsByYear W30945848652023 @default.
• W3094584865 crossrefType "journal-article" @default.
• W3094584865 hasAuthorship W3094584865A5049993782 @default.
• W3094584865 hasAuthorship W3094584865A5053771434 @default.
• W3094584865 hasAuthorship W3094584865A5057141960 @default.
• W3094584865 hasAuthorship W3094584865A5075531666 @default.
• W3094584865 hasAuthorship W3094584865A5075983414 @default.
• W3094584865 hasAuthorship W3094584865A5084900431 @default.
• W3094584865 hasAuthorship W3094584865A5089427847 @default.
• W3094584865 hasBestOaLocation W30945848652 @default.
• W3094584865 hasConcept C104317684 @default.
• W3094584865 hasConcept C126322002 @default.
• W3094584865 hasConcept C127716648 @default.
• W3094584865 hasConcept C139719470 @default.
• W3094584865 hasConcept C142724271 @default.
• W3094584865 hasConcept C15744967 @default.
• W3094584865 hasConcept C162324750 @default.
• W3094584865 hasConcept C16634123 @default.
• W3094584865 hasConcept C169760540 @default.
• W3094584865 hasConcept C204787440 @default.
• W3094584865 hasConcept C2776867660 @default.
• W3094584865 hasConcept C2778117688 @default.
• W3094584865 hasConcept C2778875871 @default.
• W3094584865 hasConcept C2779134260 @default.
• W3094584865 hasConcept C2779145073 @default.
• W3094584865 hasConcept C2779177272 @default.
• W3094584865 hasConcept C2779760398 @default.
• W3094584865 hasConcept C2781161787 @default.
• W3094584865 hasConcept C2989277270 @default.
• W3094584865 hasConcept C542102704 @default.
• W3094584865 hasConcept C55493867 @default.
• W3094584865 hasConcept C60644358 @default.
• W3094584865 hasConcept C70410870 @default.
• W3094584865 hasConcept C71924100 @default.
• W3094584865 hasConcept C86803240 @default.
• W3094584865 hasConceptScore W3094584865C104317684 @default.
• W3094584865 hasConceptScore W3094584865C126322002 @default.

• next