Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094632475> ?p ?o ?g. }
- W3094632475 endingPage "104424" @default.
- W3094632475 startingPage "104424" @default.
- W3094632475 abstract "In this paper, based on molecular hybridization, a series of [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazine was synthesized and their antiproliferative activities against 5 cancer cell lines (MGC-803, PC3, PC9, EC9706 and SMMC-7721) were evaluated. We found that most of them exhibited obvious growth inhibition effects on these tested cancer cells, especially compound 34 on PC3 cells (IC50 = 26.25 ± 0.28 nM). Meanwhile, compound 34 displayed best selectivity on PC3, compared with the other cancer cell lines, as well as excellent selectivity towards normal cell lines (Het-1A, L02 and GES-1). Further investigations demonstrated that 34 could significantly inhibit PC3 cells’ colony formation, increase cellular ROS content, suppress EGFR expression and induce apoptosis. Our findings indicate that 34 may serve as a novel lead compound for the discovery of more triazolopyrimidine derivatives with improved anticancer potency and selectivity." @default.
- W3094632475 created "2020-10-29" @default.
- W3094632475 creator A5009091258 @default.
- W3094632475 creator A5011118369 @default.
- W3094632475 creator A5019283473 @default.
- W3094632475 creator A5019365638 @default.
- W3094632475 creator A5054180910 @default.
- W3094632475 creator A5054885587 @default.
- W3094632475 creator A5055205314 @default.
- W3094632475 creator A5084050287 @default.
- W3094632475 creator A5085923882 @default.
- W3094632475 creator A5087637729 @default.
- W3094632475 date "2020-12-01" @default.
- W3094632475 modified "2023-10-14" @default.
- W3094632475 title "Novel [1,2,3]triazolo[4,5-d]pyrimidine derivatives containing hydrazone fragment as potent and selective anticancer agents" @default.
- W3094632475 cites W1976173045 @default.
- W3094632475 cites W1981732674 @default.
- W3094632475 cites W1982174962 @default.
- W3094632475 cites W2011006339 @default.
- W3094632475 cites W2019712140 @default.
- W3094632475 cites W2020789382 @default.
- W3094632475 cites W2024656127 @default.
- W3094632475 cites W2039845745 @default.
- W3094632475 cites W2041034105 @default.
- W3094632475 cites W2050019054 @default.
- W3094632475 cites W2069645996 @default.
- W3094632475 cites W2074514308 @default.
- W3094632475 cites W2084299658 @default.
- W3094632475 cites W2091101467 @default.
- W3094632475 cites W2134391501 @default.
- W3094632475 cites W2134896734 @default.
- W3094632475 cites W2164460325 @default.
- W3094632475 cites W2189153237 @default.
- W3094632475 cites W2204831895 @default.
- W3094632475 cites W2329128932 @default.
- W3094632475 cites W2329473221 @default.
- W3094632475 cites W2402946260 @default.
- W3094632475 cites W2462605598 @default.
- W3094632475 cites W2554074652 @default.
- W3094632475 cites W2593302066 @default.
- W3094632475 cites W2753565803 @default.
- W3094632475 cites W2761191448 @default.
- W3094632475 cites W2763090244 @default.
- W3094632475 cites W2770240948 @default.
- W3094632475 cites W2782794009 @default.
- W3094632475 cites W2794028627 @default.
- W3094632475 cites W2794119433 @default.
- W3094632475 cites W2908449964 @default.
- W3094632475 cites W2911188335 @default.
- W3094632475 cites W2918114906 @default.
- W3094632475 cites W2999417355 @default.
- W3094632475 cites W3013638556 @default.
- W3094632475 doi "https://doi.org/10.1016/j.bioorg.2020.104424" @default.
- W3094632475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33161253" @default.
- W3094632475 hasPublicationYear "2020" @default.
- W3094632475 type Work @default.
- W3094632475 sameAs 3094632475 @default.
- W3094632475 citedByCount "7" @default.
- W3094632475 countsByYear W30946324752022 @default.
- W3094632475 countsByYear W30946324752023 @default.
- W3094632475 crossrefType "journal-article" @default.
- W3094632475 hasAuthorship W3094632475A5009091258 @default.
- W3094632475 hasAuthorship W3094632475A5011118369 @default.
- W3094632475 hasAuthorship W3094632475A5019283473 @default.
- W3094632475 hasAuthorship W3094632475A5019365638 @default.
- W3094632475 hasAuthorship W3094632475A5054180910 @default.
- W3094632475 hasAuthorship W3094632475A5054885587 @default.
- W3094632475 hasAuthorship W3094632475A5055205314 @default.
- W3094632475 hasAuthorship W3094632475A5084050287 @default.
- W3094632475 hasAuthorship W3094632475A5085923882 @default.
- W3094632475 hasAuthorship W3094632475A5087637729 @default.
- W3094632475 hasBestOaLocation W30946324752 @default.
- W3094632475 hasConcept C109316439 @default.
- W3094632475 hasConcept C118792377 @default.
- W3094632475 hasConcept C121608353 @default.
- W3094632475 hasConcept C161790260 @default.
- W3094632475 hasConcept C185592680 @default.
- W3094632475 hasConcept C190283241 @default.
- W3094632475 hasConcept C202751555 @default.
- W3094632475 hasConcept C21951064 @default.
- W3094632475 hasConcept C2776597398 @default.
- W3094632475 hasConcept C2777752497 @default.
- W3094632475 hasConcept C2779321679 @default.
- W3094632475 hasConcept C2779707156 @default.
- W3094632475 hasConcept C2780349576 @default.
- W3094632475 hasConcept C54355233 @default.
- W3094632475 hasConcept C55493867 @default.
- W3094632475 hasConcept C62112901 @default.
- W3094632475 hasConcept C71240020 @default.
- W3094632475 hasConcept C81885089 @default.
- W3094632475 hasConcept C86803240 @default.
- W3094632475 hasConcept C96232424 @default.
- W3094632475 hasConceptScore W3094632475C109316439 @default.
- W3094632475 hasConceptScore W3094632475C118792377 @default.
- W3094632475 hasConceptScore W3094632475C121608353 @default.
- W3094632475 hasConceptScore W3094632475C161790260 @default.
- W3094632475 hasConceptScore W3094632475C185592680 @default.
- W3094632475 hasConceptScore W3094632475C190283241 @default.