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• W3094635541 abstract "Abstract Background Pulmonary manifestations are regularly reported in both human and animal filariasis. In human filariasis, the main known lung manifestations are the tropical pulmonary eosinophilia syndrome. Its duration and severity are correlated with the presence of microfilariae. Litomosoides sigmodontis is a filarial parasite residing in the pleural cavity of rodents. This model is widely used to understand the immune mechanisms that are established during infection and for the screening of therapeutic molecules. Some pulmonary manifestations during the patent phase of infection with L. sigmodontis have been described in different rodent hosts more or less permissive to infection. Methods Here, the permissive Mongolian gerbil ( Meriones unguiculatus ) was infected with L. sigmodontis . Prevalence and density of microfilariae and adult parasites were evaluated. Lungs were analyzed for pathological signatures using immunohistochemistry and 3D imaging techniques (two-photon and light sheet microscopy). Results Microfilaremia in gerbils was correlated with parasite load, as amicrofilaremic individuals had fewer parasites in their pleural cavities. Fibrotic polypoid structures were observed on both pleurae of infected gerbils. Polyps were of variable size and developed from the visceral mesothelium over the entire pleura. The larger polyps were vascularized and strongly infiltrated by immune cells such as eosinophils, macrophages or lymphocytes. The formation of these structures was induced by the presence of adult filariae since small and rare polyps were observed before patency, but they were exacerbated by the presence of gravid females and microfilariae. Conclusions Altogether, these data emphasize the role of host-specific factors in the pathogenesis of filarial infections." @default.
• W3094635541 created "2020-11-09" @default.
• W3094635541 creator A5029133770 @default.
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• W3094635541 date "2020-11-07" @default.
• W3094635541 modified "2023-10-09" @default.
• W3094635541 title "Microfilaria-dependent thoracic pathology associated with eosinophilic and fibrotic polyps in filaria-infected rodents" @default.
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• W3094635541 doi "https://doi.org/10.1186/s13071-020-04428-0" @default.
• W3094635541 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7648300" @default.
• W3094635541 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33160409" @default.
• W3094635541 hasPublicationYear "2020" @default.
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