FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094671423> ?p ?o ?g. }

• W3094671423 endingPage "e0241414" @default.
• W3094671423 startingPage "e0241414" @default.
• W3094671423 abstract "Pathogen-host interactions are important components of epidemiological research, but are scarcely investigated in chelonians. Red-eared sliders (Trachemys scripta elegans), are recognized as a model for frog virus-3 infection (FV3), a ranavirus in the family Iridoviridae that infects multiple classes of ectothermic vertebrates. Previous challenge studies observed differences in disease outcome based on environmental temperature in this species, but the host response was minimally evaluated. We challenged red-eared sliders with an FV3-like ranavirus at both 28°C and 22°C. We monitored several host response variables for 30 days, including: survival (binary outcome and duration), clinical signs, total and differential leukocytes, and select cytokine transcription in the buffy coat (IL-1β, TNFα, IFYg, IL-10). After 30 days, 17% of challenged turtles survived at 28°C (Median survival time [MST]: 15 days, range: 10–30 days) and 50% survived (MST: 28.5 days, range: 23–30 days) at 22°C (range 23–30 days). The most common clinical signs were injection site swelling, palpebral swelling, and lethargy. The heterophil/lymphocyte ratio at 22°C and interleukin-1 beta (IL1β) transcription at both 22°C and 28°C were significantly greater on days 9, 16, and 23 in FV3 challenged groups. Tumor necrosis factor alpha and interleukin-10 were transcribed at detectable levels, but did not display significant differences in mean relative transcription quantity over time. Overall, evidence indicates an over-robust immune response leading to death in the challenged turtles. FV3 remains a risk for captive and free-ranging chelonian populations, and insight to host/pathogen interaction through this model helps to elucidate the timing and intensity of the host response that contribute to mortality." @default.
• W3094671423 created "2020-11-09" @default.
• W3094671423 creator A5010594272 @default.
• W3094671423 creator A5082235914 @default.
• W3094671423 date "2020-10-29" @default.
• W3094671423 modified "2023-10-17" @default.
• W3094671423 title "Temperature affects the host hematological and cytokine response following experimental ranavirus infection in red-eared sliders (Trachemys scripta elegans)" @default.
• W3094671423 cites W1545204770 @default.
• W3094671423 cites W1968487452 @default.
• W3094671423 cites W1993280037 @default.
• W3094671423 cites W2010145864 @default.
• W3094671423 cites W2013988347 @default.
• W3094671423 cites W2052959583 @default.
• W3094671423 cites W2063342054 @default.
• W3094671423 cites W2072267350 @default.
• W3094671423 cites W2084422644 @default.
• W3094671423 cites W2090127768 @default.
• W3094671423 cites W2096152958 @default.
• W3094671423 cites W2096478498 @default.
• W3094671423 cites W2097075017 @default.
• W3094671423 cites W2102670626 @default.
• W3094671423 cites W2114390287 @default.
• W3094671423 cites W2124286943 @default.
• W3094671423 cites W2126331218 @default.
• W3094671423 cites W2128134476 @default.
• W3094671423 cites W2129239355 @default.
• W3094671423 cites W2140034263 @default.
• W3094671423 cites W2140104758 @default.
• W3094671423 cites W2140579606 @default.
• W3094671423 cites W2145057436 @default.
• W3094671423 cites W2146629293 @default.
• W3094671423 cites W2153560590 @default.
• W3094671423 cites W2158090689 @default.
• W3094671423 cites W2164802000 @default.
• W3094671423 cites W2307346383 @default.
• W3094671423 cites W2416751434 @default.
• W3094671423 cites W2465925133 @default.
• W3094671423 cites W2593563543 @default.
• W3094671423 cites W2601583467 @default.
• W3094671423 cites W2796070703 @default.
• W3094671423 cites W2806646127 @default.
• W3094671423 cites W2904553628 @default.
• W3094671423 cites W2921806689 @default.
• W3094671423 cites W3021343092 @default.
• W3094671423 cites W4243149889 @default.
• W3094671423 cites W4254687493 @default.
• W3094671423 doi "https://doi.org/10.1371/journal.pone.0241414" @default.
• W3094671423 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7595395" @default.
• W3094671423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33119713" @default.
• W3094671423 hasPublicationYear "2020" @default.
• W3094671423 type Work @default.
• W3094671423 sameAs 3094671423 @default.
• W3094671423 citedByCount "4" @default.
• W3094671423 countsByYear W30946714232023 @default.
• W3094671423 crossrefType "journal-article" @default.
• W3094671423 hasAuthorship W3094671423A5010594272 @default.
• W3094671423 hasAuthorship W3094671423A5082235914 @default.
• W3094671423 hasBestOaLocation W30946714231 @default.
• W3094671423 hasConcept C203014093 @default.
• W3094671423 hasConcept C2522874641 @default.
• W3094671423 hasConcept C2780929364 @default.
• W3094671423 hasConcept C86803240 @default.
• W3094671423 hasConceptScore W3094671423C203014093 @default.
• W3094671423 hasConceptScore W3094671423C2522874641 @default.
• W3094671423 hasConceptScore W3094671423C2780929364 @default.
• W3094671423 hasConceptScore W3094671423C86803240 @default.
• W3094671423 hasIssue "10" @default.
• W3094671423 hasLocation W30946714231 @default.
• W3094671423 hasLocation W30946714232 @default.
• W3094671423 hasLocation W30946714233 @default.
• W3094671423 hasOpenAccess W3094671423 @default.
• W3094671423 hasPrimaryLocation W30946714231 @default.
• W3094671423 hasRelatedWork W2066389586 @default.
• W3094671423 hasRelatedWork W2070160441 @default.
• W3094671423 hasRelatedWork W2127011605 @default.
• W3094671423 hasRelatedWork W2132831499 @default.
• W3094671423 hasRelatedWork W2489422176 @default.
• W3094671423 hasRelatedWork W2982669212 @default.
• W3094671423 hasRelatedWork W3010839685 @default.
• W3094671423 hasRelatedWork W3164939432 @default.
• W3094671423 hasRelatedWork W4322503696 @default.
• W3094671423 hasRelatedWork W4385602033 @default.
• W3094671423 hasVolume "15" @default.
• W3094671423 isParatext "false" @default.
• W3094671423 isRetracted "false" @default.
• W3094671423 magId "3094671423" @default.
• W3094671423 workType "article" @default.