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- W3094689931 abstract "A number of observations have suggested that in some instances activated myc oncogenes might induce in rat fibroblasts a similarly defined high-risk state. When expression of the viral-transforming gene products (T antigens) was studied in tumoral cells grown in syngeneic animals from SV40-transformed Fischer rat fibroblasts it was unexpectedly found that expression of viral proteins was not detectable in most of the tumors. The recent development of the technology for constructing transgenic strains produced already well-documented cases of insertion of active oncogenes into the germ line of laboratory mice. Cell lines selected by focus formation after infection with SV40 virus exhibit low levels of transformation, and nonselective procedures lead to the establishment of cell lines with properties even closer to those of the original normal cells. The stepwise progression of viral papillomas into malignant carcinomas has been observed in experimental animals and in naturally infected cattle." @default.
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- W3094689931 date "2020-11-25" @default.
- W3094689931 modified "2023-09-25" @default.
- W3094689931 title "Genes That Confer Susceptibility to Neoplastic Transformation on Rat Fibroblasts" @default.
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- W3094689931 doi "https://doi.org/10.1201/9781003066101-13" @default.
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