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• W3094701360 endingPage "8266" @default.
• W3094701360 startingPage "8266" @default.
• W3094701360 abstract "Preterm births are a global health priority that affects 15 million babies every year worldwide. There are no effective prognostic and therapeutic strategies relating to preterm delivery, but uterine infections appear to be a major cause. The vaginal epithelium is covered by the cervicovaginal mucus, which is essential to health because of its direct involvement in reproduction and functions as a selective barrier by sheltering the beneficial lactobacilli while helping to clear pathogens. During pregnancy, the cervical canal is sealed with a cervical mucus plug that prevents the vaginal flora from ascending toward the uterine compartment, which protects the fetus from pathogens. Abnormalities of the cervical mucus plug and bacterial vaginosis are associated with a higher risk of preterm delivery. This review addresses the current understanding of the cervicovaginal mucus and the cervical mucus plug and their interactions with the microbial communities in both the physiological state and bacterial vaginosis, with a focus on gel-forming mucins. We also review the current state of knowledge of gel-forming mucins contained in mouse cervicovaginal mucus and the mouse models used to study bacterial vaginosis." @default.
• W3094701360 created "2020-11-09" @default.
• W3094701360 creator A5001883877 @default.
• W3094701360 creator A5034643275 @default.
• W3094701360 creator A5038687992 @default.
• W3094701360 creator A5066843507 @default.
• W3094701360 date "2020-11-04" @default.
• W3094701360 modified "2023-10-03" @default.
• W3094701360 title "The Cervicovaginal Mucus Barrier" @default.
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