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• W3094737423 abstract "Small aptamer-based regulatory devices can be designed to control a range of RNA-dependent cellular processes and emerged as promising tools for fine-tuning gene expression in synthetic biology. Here, we design a conceptually new riboswitch device that allows for the conditional regulation of polyadenylation. By making use of ligand-induced sequence occlusion, the system efficiently controls the accessibility of the eukaryotic polyadenylation signal. Undesirable 3'-extended read-through products are counteracted by the downstream insertion of a microRNA target site. We demonstrate the modularity of the system with regard to sensor aptamers and polyadenylation signals used and combine the newly designed riboswitch with well-known aptazymes to yield superior composite systems. In addition, we show that the switches can be used to control alternative polyadenylation. The presented genetic switches require very little coding space and can be easily optimized by rational adjustments of the thermodynamic stability. The polyadenylation riboswitch extends the repertoire of RNA-based regulators and opens new possibilities for the generation of complex synthetic circuits." @default.
• W3094737423 created "2020-11-09" @default.
• W3094737423 creator A5053783950 @default.
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• W3094737423 date "2020-10-27" @default.
• W3094737423 modified "2023-10-01" @default.
• W3094737423 title "Aptamer-Mediated Control of Polyadenylation for Gene Expression Regulation in Mammalian Cells" @default.
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• W3094737423 doi "https://doi.org/10.1021/acssynbio.0c00222" @default.
• W3094737423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33108164" @default.
• W3094737423 hasPublicationYear "2020" @default.
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