FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094740439> ?p ?o ?g. }

• W3094740439 endingPage "546" @default.
• W3094740439 startingPage "536" @default.
• W3094740439 abstract "Hyperglycemia is a common comorbidity for ischemic stroke and is associated with worsened neurological outcomes. Platelets are central mediators of ischemic stroke and hyperglycemia mediates platelet hyperactivity. In this study, we investigated the contribution of platelet glucose metabolism to ischemic stroke.Mice lacking both Glut1 and Glut3 specifically in platelets (DKO) and their littermate controls (WT) were subjected to 1-hour transient middle cerebral artery occlusion under normoglycemic and streptozotocin-induced hyperglycemic conditions after which stroke outcomes, platelet activation, and platelet-neutrophil aggregate (PNA) formation were examined.Under normoglycemic conditions, DKO mice were protected from ischemic stroke with smaller brain infarct volumes and improved cerebral blood flow. In addition, DKO mice had reduced platelet activation, PNA, and cerebral neutrophil recruitment after stroke. Hyperglycemia significantly increased infarct size and cerebral Evans blue extravasation and worsened neurological outcomes and cerebral blood flow in both WT and DKO mice, abolishing the protective effect witnessed under normoglycemic conditions. Flow cytometric analysis after stroke demonstrated increased platelet activation and neutrophil trafficking to the brain, independent of platelet glucose metabolism. Finally, platelets from healthy DKO mice were unable to become procoagulant upon dual agonist stimulation. Conversely, hyperglycemia increased platelet mitochondrial reactive oxygen species production which potentiated procoagulant platelet formation in WT mice and restored procoagulant platelet formation in DKO mice.Hyperglycemia aggravates ischemic stroke outcome independent of platelet glucose uptake. Furthermore, we demonstrated that hyperglycemia primes procoagulant platelet formation. This underlines the therapeutic potential for strategies targeting procoagulant platelet formation for the treatment of acute ischemic stroke." @default.
• W3094740439 created "2020-11-09" @default.
• W3094740439 creator A5037659762 @default.
• W3094740439 creator A5040091180 @default.
• W3094740439 creator A5040599553 @default.
• W3094740439 creator A5091378889 @default.
• W3094740439 date "2021-02-01" @default.
• W3094740439 modified "2023-10-15" @default.
• W3094740439 title "Hyperglycemia exacerbates ischemic stroke outcome independent of platelet glucose uptake" @default.
• W3094740439 cites W1913879859 @default.
• W3094740439 cites W1969615558 @default.
• W3094740439 cites W2006447143 @default.
• W3094740439 cites W2011467994 @default.
• W3094740439 cites W2017376679 @default.
• W3094740439 cites W2021754558 @default.
• W3094740439 cites W2083314209 @default.
• W3094740439 cites W2129100727 @default.
• W3094740439 cites W2129807678 @default.
• W3094740439 cites W2133477264 @default.
• W3094740439 cites W2136976666 @default.
• W3094740439 cites W2167055129 @default.
• W3094740439 cites W2170491433 @default.
• W3094740439 cites W2173549606 @default.
• W3094740439 cites W2288433932 @default.
• W3094740439 cites W2333530839 @default.
• W3094740439 cites W2463742113 @default.
• W3094740439 cites W2514595878 @default.
• W3094740439 cites W2523917817 @default.
• W3094740439 cites W2597739224 @default.
• W3094740439 cites W2613572458 @default.
• W3094740439 cites W2614835650 @default.
• W3094740439 cites W2736776512 @default.
• W3094740439 cites W2737964114 @default.
• W3094740439 cites W2758334268 @default.
• W3094740439 cites W2781994781 @default.
• W3094740439 cites W2794065164 @default.
• W3094740439 cites W2804639161 @default.
• W3094740439 cites W2889924013 @default.
• W3094740439 cites W2899369568 @default.
• W3094740439 cites W2911428870 @default.
• W3094740439 cites W2916318346 @default.
• W3094740439 cites W2918067884 @default.
• W3094740439 cites W2939298916 @default.
• W3094740439 cites W2957572140 @default.
• W3094740439 cites W2964070886 @default.
• W3094740439 cites W2967478617 @default.
• W3094740439 cites W2994321509 @default.
• W3094740439 cites W3007071978 @default.
• W3094740439 doi "https://doi.org/10.1111/jth.15154" @default.
• W3094740439 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7902465" @default.
• W3094740439 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33118271" @default.
• W3094740439 hasPublicationYear "2021" @default.
• W3094740439 type Work @default.
• W3094740439 sameAs 3094740439 @default.
• W3094740439 citedByCount "15" @default.
• W3094740439 countsByYear W30947404392021 @default.
• W3094740439 countsByYear W30947404392022 @default.
• W3094740439 countsByYear W30947404392023 @default.
• W3094740439 crossrefType "journal-article" @default.
• W3094740439 hasAuthorship W3094740439A5037659762 @default.
• W3094740439 hasAuthorship W3094740439A5040091180 @default.
• W3094740439 hasAuthorship W3094740439A5040599553 @default.
• W3094740439 hasAuthorship W3094740439A5091378889 @default.
• W3094740439 hasBestOaLocation W30947404391 @default.
• W3094740439 hasConcept C126322002 @default.
• W3094740439 hasConcept C127413603 @default.
• W3094740439 hasConcept C134018914 @default.
• W3094740439 hasConcept C157767197 @default.
• W3094740439 hasConcept C161573976 @default.
• W3094740439 hasConcept C2779306644 @default.
• W3094740439 hasConcept C2780645631 @default.
• W3094740439 hasConcept C3018697912 @default.
• W3094740439 hasConcept C42219234 @default.
• W3094740439 hasConcept C541997718 @default.
• W3094740439 hasConcept C71924100 @default.
• W3094740439 hasConcept C78519656 @default.
• W3094740439 hasConcept C89560881 @default.
• W3094740439 hasConceptScore W3094740439C126322002 @default.
• W3094740439 hasConceptScore W3094740439C127413603 @default.
• W3094740439 hasConceptScore W3094740439C134018914 @default.
• W3094740439 hasConceptScore W3094740439C157767197 @default.
• W3094740439 hasConceptScore W3094740439C161573976 @default.
• W3094740439 hasConceptScore W3094740439C2779306644 @default.
• W3094740439 hasConceptScore W3094740439C2780645631 @default.
• W3094740439 hasConceptScore W3094740439C3018697912 @default.
• W3094740439 hasConceptScore W3094740439C42219234 @default.
• W3094740439 hasConceptScore W3094740439C541997718 @default.
• W3094740439 hasConceptScore W3094740439C71924100 @default.
• W3094740439 hasConceptScore W3094740439C78519656 @default.
• W3094740439 hasConceptScore W3094740439C89560881 @default.
• W3094740439 hasFunder F4320337337 @default.
• W3094740439 hasFunder F4320337359 @default.
• W3094740439 hasIssue "2" @default.
• W3094740439 hasLocation W30947404391 @default.
• W3094740439 hasLocation W30947404392 @default.
• W3094740439 hasLocation W30947404393 @default.
• W3094740439 hasOpenAccess W3094740439 @default.
• W3094740439 hasPrimaryLocation W30947404391 @default.

• next