Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094753192> ?p ?o ?g. }
- W3094753192 abstract "ABSTRACT RAS genes are the most frequently mutated oncogenes in cancer. However, the effects of oncogenic RAS signaling on the noncoding transcriptome are unclear. We analyzed the transcriptomes of human airway epithelial cells transformed with mutant KRAS to define the landscape of KRAS-regulated noncoding RNAs. We found that oncogenic KRAS upregulates noncoding transcripts throughout the genome, many of which arise from transposable elements. These repetitive noncoding RNAs exhibit differential RNA editing in single cells, are released in extracellular vesicles, and are known targets of KRAB zinc-finger proteins, which are broadly down-regulated in mutant KRAS cells and lung adenocarcinomas. Moreover, mutant KRAS induces IFN-stimulated genes through both epigenetic and RNA-based mechanisms. Our results reveal that mutant KRAS remodels the noncoding transcriptome through epigenomic reprogramming, expanding the scope of genomic elements regulated by this fundamental signaling pathway and revealing how mutant KRAS induces an intrinsic IFN-stimulated gene signature often seen in ADAR-dependent cancers." @default.
- W3094753192 created "2020-11-09" @default.
- W3094753192 creator A5005939272 @default.
- W3094753192 creator A5007110929 @default.
- W3094753192 creator A5024139629 @default.
- W3094753192 creator A5027426739 @default.
- W3094753192 creator A5028618576 @default.
- W3094753192 creator A5035793503 @default.
- W3094753192 creator A5040482039 @default.
- W3094753192 creator A5046338207 @default.
- W3094753192 creator A5046688257 @default.
- W3094753192 creator A5057927472 @default.
- W3094753192 creator A5075638451 @default.
- W3094753192 creator A5076317546 @default.
- W3094753192 creator A5080664237 @default.
- W3094753192 creator A5091466840 @default.
- W3094753192 date "2020-11-04" @default.
- W3094753192 modified "2023-09-29" @default.
- W3094753192 title "Epigenomic reprogramming of repetitive noncoding RNAs and IFN-stimulated genes by mutant KRAS" @default.
- W3094753192 cites W1807400738 @default.
- W3094753192 cites W1905278501 @default.
- W3094753192 cites W1953890763 @default.
- W3094753192 cites W1987754123 @default.
- W3094753192 cites W1994772304 @default.
- W3094753192 cites W2006019980 @default.
- W3094753192 cites W2014677321 @default.
- W3094753192 cites W2107454957 @default.
- W3094753192 cites W2108234281 @default.
- W3094753192 cites W2131271579 @default.
- W3094753192 cites W2163032823 @default.
- W3094753192 cites W2166810745 @default.
- W3094753192 cites W2168909179 @default.
- W3094753192 cites W2169456326 @default.
- W3094753192 cites W2179438025 @default.
- W3094753192 cites W2180481128 @default.
- W3094753192 cites W2197124664 @default.
- W3094753192 cites W2346937970 @default.
- W3094753192 cites W2462305122 @default.
- W3094753192 cites W2592811885 @default.
- W3094753192 cites W2594086611 @default.
- W3094753192 cites W2620721366 @default.
- W3094753192 cites W2623862783 @default.
- W3094753192 cites W2732767128 @default.
- W3094753192 cites W2748710555 @default.
- W3094753192 cites W2765997581 @default.
- W3094753192 cites W2793752318 @default.
- W3094753192 cites W2795622837 @default.
- W3094753192 cites W2805588652 @default.
- W3094753192 cites W2903723780 @default.
- W3094753192 cites W2903746377 @default.
- W3094753192 cites W2949177718 @default.
- W3094753192 cites W2981114707 @default.
- W3094753192 cites W2982780080 @default.
- W3094753192 cites W3014463300 @default.
- W3094753192 cites W3036354173 @default.
- W3094753192 doi "https://doi.org/10.1101/2020.11.04.367771" @default.
- W3094753192 hasPublicationYear "2020" @default.
- W3094753192 type Work @default.
- W3094753192 sameAs 3094753192 @default.
- W3094753192 citedByCount "5" @default.
- W3094753192 countsByYear W30947531922021 @default.
- W3094753192 countsByYear W30947531922022 @default.
- W3094753192 countsByYear W30947531922023 @default.
- W3094753192 crossrefType "posted-content" @default.
- W3094753192 hasAuthorship W3094753192A5005939272 @default.
- W3094753192 hasAuthorship W3094753192A5007110929 @default.
- W3094753192 hasAuthorship W3094753192A5024139629 @default.
- W3094753192 hasAuthorship W3094753192A5027426739 @default.
- W3094753192 hasAuthorship W3094753192A5028618576 @default.
- W3094753192 hasAuthorship W3094753192A5035793503 @default.
- W3094753192 hasAuthorship W3094753192A5040482039 @default.
- W3094753192 hasAuthorship W3094753192A5046338207 @default.
- W3094753192 hasAuthorship W3094753192A5046688257 @default.
- W3094753192 hasAuthorship W3094753192A5057927472 @default.
- W3094753192 hasAuthorship W3094753192A5075638451 @default.
- W3094753192 hasAuthorship W3094753192A5076317546 @default.
- W3094753192 hasAuthorship W3094753192A5080664237 @default.
- W3094753192 hasAuthorship W3094753192A5091466840 @default.
- W3094753192 hasBestOaLocation W30947531921 @default.
- W3094753192 hasConcept C104317684 @default.
- W3094753192 hasConcept C117717151 @default.
- W3094753192 hasConcept C121912465 @default.
- W3094753192 hasConcept C143065580 @default.
- W3094753192 hasConcept C150194340 @default.
- W3094753192 hasConcept C162317418 @default.
- W3094753192 hasConcept C190727270 @default.
- W3094753192 hasConcept C194993378 @default.
- W3094753192 hasConcept C2781187634 @default.
- W3094753192 hasConcept C41091548 @default.
- W3094753192 hasConcept C501734568 @default.
- W3094753192 hasConcept C54355233 @default.
- W3094753192 hasConcept C62203573 @default.
- W3094753192 hasConcept C67705224 @default.
- W3094753192 hasConcept C77255625 @default.
- W3094753192 hasConcept C86803240 @default.
- W3094753192 hasConcept C95444343 @default.
- W3094753192 hasConceptScore W3094753192C104317684 @default.
- W3094753192 hasConceptScore W3094753192C117717151 @default.
- W3094753192 hasConceptScore W3094753192C121912465 @default.
- W3094753192 hasConceptScore W3094753192C143065580 @default.