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- W3094756898 startingPage "57" @default.
- W3094756898 abstract "Pioneering experiments performed by Harold Varmus and Mike Bishop in 1976 led to one of the most influential discoveries in cancer research and identified the first cancer-causing oncogene called Src. Later experimental and clinical evidence suggested that Src kinase plays a significant role in promoting tumor growth and progression and its activity is associated with poor patient survival. Thus, several Src inhibitors were developed and approved by FDA for treatment of cancer patients. Tumor microenvironment (TME) is a highly complex and dynamic milieu where significant cross-talk occurs between cancer cells and TME components, which consist of tumor-associated macrophages, fibroblasts, and other immune and vascular cells. Growth factors and chemokines activate multiple signaling cascades in TME and induce multiple kinases and pathways, including Src, leading to tumor growth, invasion/metastasis, angiogenesis, drug resistance, and progression. Here, we will systemically evaluate recent findings regarding regulation of Src and significance of targeting Src in cancer therapy." @default.
- W3094756898 created "2020-11-09" @default.
- W3094756898 creator A5015430271 @default.
- W3094756898 creator A5019366364 @default.
- W3094756898 creator A5040193650 @default.
- W3094756898 date "2020-10-30" @default.
- W3094756898 modified "2023-09-23" @default.
- W3094756898 title "SRC Signaling in Cancer and Tumor Microenvironment" @default.
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