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- W3094758215 abstract "Penicillin-binding proteins (PBPs), the proteins catalyzing the last steps of peptidoglycan assembly, are critical for bacteria to maintain cell size, shape, and integrity. PBPs are consequently attractive targets for antibiotics. Resistance to antibiotics in Streptococcus pneumoniae (the pneumococcus) are often associated with mutations in the PBPs. In this work, we describe a new protein, CozEb, controlling the cell size of pneumococcus. CozEb is a highly conserved integral membrane protein that works together with other proteins to regulate PBPs and peptidoglycan synthesis. Deciphering the intricate mechanisms by which the pneumococcus controls peptidoglycan assembly might allow the design of innovative anti-infective strategies, for example, by resensitizing resistant strains to PBP-targeting antibiotics." @default.
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- W3094758215 date "2020-10-27" @default.
- W3094758215 modified "2023-10-13" @default.
- W3094758215 title "A CozE Homolog Contributes to Cell Size Homeostasis of Streptococcus pneumoniae" @default.
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- W3094758215 doi "https://doi.org/10.1128/mbio.02461-20" @default.
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