Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094764294> ?p ?o ?g. }
- W3094764294 endingPage "8259" @default.
- W3094764294 startingPage "8259" @default.
- W3094764294 abstract "The target of rapamycin (TOR) is an evolutionarily-conserved serine/threonine kinase that senses and integrates signals from the environment to coordinate developmental and metabolic processes. TOR senses nutrients, hormones, metabolites, and stress signals to promote cell and organ growth when conditions are favorable. However, TOR is inhibited when conditions are unfavorable, promoting catabolic processes such as autophagy. Autophagy is a macromolecular degradation pathway by which cells degrade and recycle cytoplasmic materials. TOR negatively regulates autophagy through phosphorylation of ATG13, preventing activation of the autophagy-initiating ATG1-ATG13 kinase complex. Here we review TOR complex composition and function in photosynthetic and non-photosynthetic organisms. We also review recent developments in the identification of upstream TOR activators and downstream effectors of TOR. Finally, we discuss recent developments in our understanding of the regulation of autophagy by TOR in photosynthetic organisms." @default.
- W3094764294 created "2020-11-09" @default.
- W3094764294 creator A5031133966 @default.
- W3094764294 creator A5032410777 @default.
- W3094764294 creator A5082683941 @default.
- W3094764294 date "2020-11-04" @default.
- W3094764294 modified "2023-10-17" @default.
- W3094764294 title "Target of Rapamycin in Control of Autophagy: Puppet Master and Signal Integrator" @default.
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