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• W3094785332 abstract "Abstract The progressive consumption growth of non-steroidal anti-inflammatory drugs (NSAIDs) has progressively raised the attention toward the gastrointestinal, renal, and cardiovascular toxicity. Increased risk of cardiovascular diseases was strictly associated with the usage of COX-2 selective NSAIDs. Other studies allowed to clarify that the cardiovascular risk is not limited to COX-2 selective but also extended to non-selective NSAIDs, such as Diclofenac and Ketoprofen. To date, although a less favorable cardiovascular risk profile for Diclofenac as compared to Ketoprofen is reported, the mechanisms through which NSAIDs cause adverse cardiovascular events are not entirely understood. The present study aimed to evaluate the effects of Ketoprofen in comparison with Diclofenac in immortalized human cardiomyocytes. The results obtained highlight the dose-dependent cardiotoxicity of Diclofenac compared to Ketoprofen. Despite both drugs induce the increase in ROS production, decrease of mitochondrial membrane potential, and proteasome activity modulation, only Diclofenac exposure shows a marked alteration of these intracellular parameters, leading to cell death. Noteworthy, Diclofenac decreases the proteasome 26S DC and this scenario may be dependent on the intracellular overload of oxidized proteins. The data support the hypothesis that immortalized human cardiomyocytes exposed to Ketoprofen are subjected to tolerable stress events, conversely Diclofenac exposition triggers cell death." @default.
• W3094785332 created "2020-11-09" @default.
• W3094785332 creator A5003973455 @default.
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• W3094785332 date "2020-10-27" @default.
• W3094785332 modified "2023-09-26" @default.
• W3094785332 title "NSAIDs-dependent adaption of the mitochondria-proteasome system in immortalized human cardiomyocytes" @default.
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• W3094785332 doi "https://doi.org/10.1038/s41598-020-75394-x" @default.
• W3094785332 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7591859" @default.
• W3094785332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33110169" @default.
• W3094785332 hasPublicationYear "2020" @default.
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