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- W3094790273 endingPage "10375" @default.
- W3094790273 startingPage "10361" @default.
- W3094790273 abstract "With the widespread implementation of lung cancer screening, more and more patients are being diagnosed with multiple primary lung cancers (MPLCs). In the era of precision medicine, many controversies remain in differentiating MPLCs from intrapulmonary metastasis and the optimum treatment choice, especially in patients exhibiting similar histology. In this review, we summarize common diagnostic criteria and novel discrimination methods with a special emphasis on the emerging value of broad panel next-generation sequencing (NGS) for the diagnosis of MPLCs. We then discuss current advances regarding therapeutic approaches for MPLCs. Radical surgery is the main treatment modality, while stereotactic body radiotherapy (SBRT) is safe and feasible for early-stage MPLC patients with inoperable tumors. In addition, immunotherapy and targeted therapy, particularly epidermal growth factor receptor-tyrosine kinase inhibitors, are emerging therapeutic strategies that are still in their infancy. Characteristics of both genomic profiles and tumor microenvironment are currently being evaluated but warrant further exploration to facilitate the application of targeted systematic therapies in MPLC patients." @default.
- W3094790273 created "2020-11-09" @default.
- W3094790273 creator A5007325506 @default.
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- W3094790273 creator A5032070906 @default.
- W3094790273 creator A5043419648 @default.
- W3094790273 creator A5088681354 @default.
- W3094790273 date "2020-10-01" @default.
- W3094790273 modified "2023-09-30" @default.
- W3094790273 title "<p>Multiple Primary Lung Cancers: A New Challenge in the Era of Precision Medicine</p>" @default.
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