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• W3094811096 abstract "In this Current Opinion, we highlight the importance of the material properties of tissues and how alterations therein, which influence epithelial-to-mesenchymal transitions, represent an important layer of regulation in a number of diseases and potentially also play a critical role in host-pathogen interactions. In light of the current SARS-CoV-2 pandemic, we here highlight the possible role of lung tissue stiffening with ageing and how this might facilitate increased SARS-CoV-2 replication through matrix-stiffness dependent epithelial-to-mesenchymal transitions of the lung epithelium. This emphasizes the need for integrating material properties of tissues in drug discovery programs." @default.
• W3094811096 created "2020-11-09" @default.
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• W3094811096 date "2021-02-01" @default.
• W3094811096 modified "2023-10-16" @default.
• W3094811096 title "Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity" @default.
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• W3094811096 doi "https://doi.org/10.1016/j.cossms.2020.100874" @default.
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