Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094816479> ?p ?o ?g. }
- W3094816479 endingPage "395" @default.
- W3094816479 startingPage "384" @default.
- W3094816479 abstract "Paxillin (PXN), a key component of the focal adhesion complex, has been associated with cancer progression, but the underlying mechanisms are poorly understood. The purpose of this study was to elucidate mechanisms by which PXN affects cancer growth and progression, which we addressed using cancer patient data, cell lines, and orthotopic mouse models. We demonstrated a previously unrecognized mechanism whereby nuclear PXN enhances angiogenesis by transcriptionally regulating SRC expression. SRC, in turn, increases PLAT expression through NF-ĸB activation; PLAT promotes angiogenesis via LRP1 in endothelial cells. PXN silencing in ovarian cancer mouse models reduced angiogenesis, tumor growth, and metastasis. These findings provide a new understanding of the role of PXN in regulating tumor angiogenesis and growth." @default.
- W3094816479 created "2020-11-09" @default.
- W3094816479 creator A5009718297 @default.
- W3094816479 creator A5010129570 @default.
- W3094816479 creator A5012092656 @default.
- W3094816479 creator A5019650612 @default.
- W3094816479 creator A5020081483 @default.
- W3094816479 creator A5021604770 @default.
- W3094816479 creator A5022598004 @default.
- W3094816479 creator A5023542865 @default.
- W3094816479 creator A5027588399 @default.
- W3094816479 creator A5033319933 @default.
- W3094816479 creator A5042760638 @default.
- W3094816479 creator A5043392987 @default.
- W3094816479 creator A5044349562 @default.
- W3094816479 creator A5082498438 @default.
- W3094816479 creator A5089092419 @default.
- W3094816479 date "2020-11-04" @default.
- W3094816479 modified "2023-10-18" @default.
- W3094816479 title "The hidden role of paxillin: localization to nucleus promotes tumor angiogenesis" @default.
- W3094816479 cites W1964437080 @default.
- W3094816479 cites W1970213932 @default.
- W3094816479 cites W1994468109 @default.
- W3094816479 cites W1996537616 @default.
- W3094816479 cites W2030413647 @default.
- W3094816479 cites W2032730095 @default.
- W3094816479 cites W2039737850 @default.
- W3094816479 cites W2042877805 @default.
- W3094816479 cites W2050018959 @default.
- W3094816479 cites W2059552745 @default.
- W3094816479 cites W2089808841 @default.
- W3094816479 cites W2101890463 @default.
- W3094816479 cites W2112418598 @default.
- W3094816479 cites W2113783145 @default.
- W3094816479 cites W2122560124 @default.
- W3094816479 cites W2129825215 @default.
- W3094816479 cites W2132642214 @default.
- W3094816479 cites W2133056134 @default.
- W3094816479 cites W2137761999 @default.
- W3094816479 cites W2146542802 @default.
- W3094816479 cites W2156752428 @default.
- W3094816479 cites W2158037819 @default.
- W3094816479 cites W2170488331 @default.
- W3094816479 cites W2170950610 @default.
- W3094816479 cites W2310034942 @default.
- W3094816479 cites W2317723771 @default.
- W3094816479 cites W2335964622 @default.
- W3094816479 cites W2588121804 @default.
- W3094816479 cites W2766475448 @default.
- W3094816479 cites W2949922878 @default.
- W3094816479 cites W3028594675 @default.
- W3094816479 cites W3037473453 @default.
- W3094816479 doi "https://doi.org/10.1038/s41388-020-01517-3" @default.
- W3094816479 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8275353" @default.
- W3094816479 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33149280" @default.
- W3094816479 hasPublicationYear "2020" @default.
- W3094816479 type Work @default.
- W3094816479 sameAs 3094816479 @default.
- W3094816479 citedByCount "15" @default.
- W3094816479 countsByYear W30948164792020 @default.
- W3094816479 countsByYear W30948164792021 @default.
- W3094816479 countsByYear W30948164792022 @default.
- W3094816479 countsByYear W30948164792023 @default.
- W3094816479 crossrefType "journal-article" @default.
- W3094816479 hasAuthorship W3094816479A5009718297 @default.
- W3094816479 hasAuthorship W3094816479A5010129570 @default.
- W3094816479 hasAuthorship W3094816479A5012092656 @default.
- W3094816479 hasAuthorship W3094816479A5019650612 @default.
- W3094816479 hasAuthorship W3094816479A5020081483 @default.
- W3094816479 hasAuthorship W3094816479A5021604770 @default.
- W3094816479 hasAuthorship W3094816479A5022598004 @default.
- W3094816479 hasAuthorship W3094816479A5023542865 @default.
- W3094816479 hasAuthorship W3094816479A5027588399 @default.
- W3094816479 hasAuthorship W3094816479A5033319933 @default.
- W3094816479 hasAuthorship W3094816479A5042760638 @default.
- W3094816479 hasAuthorship W3094816479A5043392987 @default.
- W3094816479 hasAuthorship W3094816479A5044349562 @default.
- W3094816479 hasAuthorship W3094816479A5082498438 @default.
- W3094816479 hasAuthorship W3094816479A5089092419 @default.
- W3094816479 hasBestOaLocation W30948164792 @default.
- W3094816479 hasConcept C116581196 @default.
- W3094816479 hasConcept C121608353 @default.
- W3094816479 hasConcept C151166631 @default.
- W3094816479 hasConcept C2779013556 @default.
- W3094816479 hasConcept C2779256057 @default.
- W3094816479 hasConcept C2780394083 @default.
- W3094816479 hasConcept C502942594 @default.
- W3094816479 hasConcept C54355233 @default.
- W3094816479 hasConcept C62478195 @default.
- W3094816479 hasConcept C86803240 @default.
- W3094816479 hasConcept C95444343 @default.
- W3094816479 hasConceptScore W3094816479C116581196 @default.
- W3094816479 hasConceptScore W3094816479C121608353 @default.
- W3094816479 hasConceptScore W3094816479C151166631 @default.
- W3094816479 hasConceptScore W3094816479C2779013556 @default.
- W3094816479 hasConceptScore W3094816479C2779256057 @default.
- W3094816479 hasConceptScore W3094816479C2780394083 @default.
- W3094816479 hasConceptScore W3094816479C502942594 @default.