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• W3094865191 endingPage "101762" @default.
• W3094865191 startingPage "101762" @default.
• W3094865191 abstract "Vision is essential for vertebrates including humans. Sustained vision is accomplished by retinoid metabolism, the visual cycle, where all-trans retinol (atROL) is incorporated into the retinal pigment epithelium (RPE) from photoreceptors presumably through decade-long missing receptor(s). Here, we show that the LDL-related receptor-5 (Lrp5) protein is linked to the retinol binding protein 1a (Rbp1a), the transporter of atROL in the visual cycle, by generating and analyzing the digenic eyes shut homolog+/- ; lrp5+/- zebrafish, the same form of gene defect detected in a human case of inherited retinal degeneration. Global gene expression analysis followed by genetic study clarified that rbp1a played a role downstream of lrp5. Rbp1a protein was colocalized with Lrp5 protein at microvilli of RPE cells. Furthermore, Rbp1a directly bound to the C-terminal intracellular region of Lrp5 in vitro. Collectively, these results strongly suggest that Lrp5 is a potent candidate of the receptor of atROL in the visual cycle." @default.
• W3094865191 created "2020-11-09" @default.
• W3094865191 creator A5052557173 @default.
• W3094865191 creator A5076239285 @default.
• W3094865191 date "2020-12-01" @default.
• W3094865191 modified "2023-09-26" @default.
• W3094865191 title "eys; lrp5 Zebrafish Reveals Lrp5 Can Be the Receptor of Retinol in the Visual Cycle" @default.
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• W3094865191 doi "https://doi.org/10.1016/j.isci.2020.101762" @default.
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