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- W3094865307 endingPage "1048" @default.
- W3094865307 startingPage "1020" @default.
- W3094865307 abstract "There is an ongoing shift in demographics such that older persons will outnumber young persons in the coming years, and with it age-associated tissue attrition and increased diseases and disorders. There has been increased information on the association of the aging process with dysregulation of hematopoietic stem (HSC) and progenitor (HPC) cells, and hematopoiesis. This review provides an extensive up-to date summary on the literature of aged hematopoiesis and HSCs placed in context of potential artifacts of the collection and processing procedure, that may not be totally representative of the status of HSCs in their in vivo bone marrow microenvironment, and what the implications of this are for understanding aged hematopoiesis. This review covers a number of interactive areas, many of which have not been adequately explored. There are still many unknowns and mechanistic insights to be elucidated to better understand effects of aging on the hematopoietic system, efforts that will take multidisciplinary approaches, and that could lead to means to ameliorate at least some of the dysregulation of HSCs and HPCs associated with the aging process." @default.
- W3094865307 created "2020-11-09" @default.
- W3094865307 creator A5000603569 @default.
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- W3094865307 creator A5041715142 @default.
- W3094865307 creator A5070264488 @default.
- W3094865307 date "2020-11-03" @default.
- W3094865307 modified "2023-10-17" @default.
- W3094865307 title "Fate of Hematopoiesis During Aging. What Do We Really Know, and What are its Implications?" @default.
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