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- W3094865677 abstract "Rationale: Cardiovascular comorbidities are prevalent in patients after lung transplantation (LTX). While sleep apnea is known to be associated with cardiovascular problems, data concerning sleep apnea (SA) after LTX are scarce. The aim of this study is to analyze prevalence, associated factors and impact on survival of moderate to severe SA in a large cohort of consecutive LTX patients. Methods: Patients (n=219, 50,2% females) transplanted between February 2013 and March 2017 underwent a diagnostic polysomnography 1 year after LTX. Results: Moderate to severe SA was present in 57.5% of patients. SA patients were older, mostly male (57.9%) and had a higher BMI and neck circumference. The prevalence of moderate to severe SA was highest in COPD/emphysema patients (86/121; 71.1%) and pulmonary fibrosis (28/43; 65.1%). Nighttime diastolic and 24-hour blood pressures were higher in SA patients. Compared to pre-LTX, mean apnoea/hypopnoea index (AHI) increased significantly after LTX. A significant correlation was seen between lung function parameters and AHI. Presence of SA had no significant impact on mortality or prevalence of chronic lung allograft dysfunction. However, survival was significantly better in CPAP compliant SA patients compared to SA patients without CPAP treatment. Conclusion: The prevalence of SA one year after LTX was high, especially in patients with pre-LTX emphysema and pulmonary fibrosis. SA after LTX was associated with anthropometric, lung function parameters and higher blood pressure. CPAP compliant patients had a better survival than SA patients without CPAP treatment. These findings may ask for systemic screening of SA after LTX." @default.
- W3094865677 created "2020-11-09" @default.
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- W3094865677 date "2020-09-07" @default.
- W3094865677 modified "2023-10-17" @default.
- W3094865677 title "Sleep apnea after lung transplantation: a cohort study" @default.
- W3094865677 doi "https://doi.org/10.1183/13993003.congress-2020.2507" @default.
- W3094865677 hasPublicationYear "2020" @default.
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