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- W3094893995 endingPage "332" @default.
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- W3094893995 abstract "Abstract Bruton’s tyrosine kinase (BTK) inhibitor is a promising novel agent that has potential efficiency in B-cell malignancies. It took approximately 20 years from target discovery to new drug approval. The first-in-class drug ibrutinib creates possibilities for an era of chemotherapy-free management of B-cell malignancies, and it is so popular that gross sales have rapidly grown to more than 230 billion dollars in just 6 years, with annual sales exceeding 80 billion dollars; it also became one of the five top-selling medicines in the world. Numerous clinical trials of BTK inhibitors in cancers were initiated in the last decade, and ~73 trials were intensively announced or updated with extended follow-up data in the most recent 3 years. In this review, we summarized the significant milestones in the preclinical discovery and clinical development of BTK inhibitors to better understand the clinical and commercial potential as well as the directions being taken. Furthermore, it also contributes impactful lessons regarding the discovery and development of other novel therapies." @default.
- W3094893995 created "2020-11-09" @default.
- W3094893995 creator A5019874488 @default.
- W3094893995 creator A5039045967 @default.
- W3094893995 creator A5048141581 @default.
- W3094893995 creator A5050044488 @default.
- W3094893995 creator A5050988890 @default.
- W3094893995 date "2020-10-29" @default.
- W3094893995 modified "2023-10-16" @default.
- W3094893995 title "Inhibitors targeting Bruton’s tyrosine kinase in cancers: drug development advances" @default.
- W3094893995 cites W1020989877 @default.
- W3094893995 cites W1965742783 @default.
- W3094893995 cites W1974084203 @default.
- W3094893995 cites W1993345471 @default.
- W3094893995 cites W1997362383 @default.
- W3094893995 cites W2001774222 @default.
- W3094893995 cites W2006422013 @default.
- W3094893995 cites W2013909810 @default.
- W3094893995 cites W2019216438 @default.
- W3094893995 cites W2023976667 @default.
- W3094893995 cites W2028681024 @default.
- W3094893995 cites W2030263904 @default.
- W3094893995 cites W2052855201 @default.
- W3094893995 cites W2060303297 @default.
- W3094893995 cites W2062457956 @default.
- W3094893995 cites W2067064694 @default.
- W3094893995 cites W2069809502 @default.
- W3094893995 cites W2071549499 @default.
- W3094893995 cites W2077190302 @default.
- W3094893995 cites W2085346499 @default.
- W3094893995 cites W2095099120 @default.
- W3094893995 cites W2095669071 @default.
- W3094893995 cites W2098002594 @default.
- W3094893995 cites W2113764179 @default.
- W3094893995 cites W2120319857 @default.
- W3094893995 cites W2125678285 @default.
- W3094893995 cites W2131823788 @default.
- W3094893995 cites W2133192145 @default.
- W3094893995 cites W2140395974 @default.
- W3094893995 cites W2142604595 @default.
- W3094893995 cites W2143766748 @default.
- W3094893995 cites W2144648936 @default.
- W3094893995 cites W2154066874 @default.
- W3094893995 cites W2154626333 @default.
- W3094893995 cites W2157749844 @default.
- W3094893995 cites W2157799317 @default.
- W3094893995 cites W2163690533 @default.
- W3094893995 cites W2171771895 @default.
- W3094893995 cites W2187899653 @default.
- W3094893995 cites W2190884983 @default.
- W3094893995 cites W2191219754 @default.
- W3094893995 cites W2195033221 @default.
- W3094893995 cites W2233614027 @default.
- W3094893995 cites W2238159161 @default.
- W3094893995 cites W2296618733 @default.
- W3094893995 cites W2316021978 @default.
- W3094893995 cites W2497974852 @default.
- W3094893995 cites W2510982931 @default.
- W3094893995 cites W2518731208 @default.
- W3094893995 cites W2519500141 @default.
- W3094893995 cites W2528264979 @default.
- W3094893995 cites W2532772806 @default.
- W3094893995 cites W2557010481 @default.
- W3094893995 cites W2570921003 @default.
- W3094893995 cites W2582696216 @default.
- W3094893995 cites W2587684973 @default.
- W3094893995 cites W2591243927 @default.
- W3094893995 cites W2625473279 @default.
- W3094893995 cites W2748428998 @default.
- W3094893995 cites W2750906538 @default.
- W3094893995 cites W2765414225 @default.
- W3094893995 cites W2774522106 @default.
- W3094893995 cites W2782689871 @default.
- W3094893995 cites W2786522183 @default.
- W3094893995 cites W2787370436 @default.
- W3094893995 cites W2787863642 @default.
- W3094893995 cites W2790448887 @default.
- W3094893995 cites W2791154088 @default.
- W3094893995 cites W2792326760 @default.
- W3094893995 cites W2792847208 @default.
- W3094893995 cites W2795301499 @default.
- W3094893995 cites W2796102942 @default.
- W3094893995 cites W2803298831 @default.
- W3094893995 cites W2805689516 @default.
- W3094893995 cites W2806493073 @default.
- W3094893995 cites W2884164278 @default.
- W3094893995 cites W2897636215 @default.
- W3094893995 cites W2898859429 @default.
- W3094893995 cites W2902484351 @default.
- W3094893995 cites W2902706178 @default.
- W3094893995 cites W2910063137 @default.
- W3094893995 cites W2914575774 @default.
- W3094893995 cites W2922286357 @default.
- W3094893995 cites W2923453543 @default.
- W3094893995 cites W2931464937 @default.
- W3094893995 cites W2943984860 @default.
- W3094893995 cites W2945468305 @default.
- W3094893995 cites W2952307708 @default.