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• W3094920708 abstract "ABSTRACT The lipid raft hypothesis postulates that cell membranes possess some degree of lateral organization. The last decade has seen a large amount of experimental evidence for rafts. Yet, the underlying mechanism remains elusive. One hypothesis that supports rafts relies on the membrane to lie near a critical point. While supported by experimental evidence, the role of regulation is unclear. Using both a lattice model and molecular dynamics simulations, we show that lipid regulation of a many-component membrane can lead to critical behavior over a large temperature range. Across this range, the membrane displays a critical composition due to finite-size effects. This mechanism provides a rationale as to how cells tune their composition without the need for specific sensing mechanisms. It is robust and reproduces important experimentally verified biological trends: membrane-demixing temperature closely follows cell growth temperature, and the composition evolves along a critical manifold. The simplicity of the mechanism provides a strong argument in favor of the critical membrane hypothesis. SIGNIFICANCE We show that biological regulation of a large amount of phospholipids in membranes naturally leads to a critical composition for finite-size systems. This suggests that regulating a system near a critical point is trivial for cells. These effects vanish logarithmically and therefore can be present in micron-sized systems." @default.
• W3094920708 created "2020-11-09" @default.
• W3094920708 creator A5005535171 @default.
• W3094920708 creator A5030571098 @default.
• W3094920708 date "2020-11-05" @default.
• W3094920708 modified "2023-09-23" @default.
• W3094920708 title "Finite-size transitions in complex membranes" @default.
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• W3094920708 doi "https://doi.org/10.1101/2020.11.05.370189" @default.
• W3094920708 hasPublicationYear "2020" @default.
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