Matches in SemOpenAlex for { <https://semopenalex.org/work/W3094951569> ?p ?o ?g. }
- W3094951569 abstract "Abstract Antimicrobial resistance poses a great danger to humanity, in part due to the widespread horizontal gene transfer of plasmids via conjugation. Modeling of plasmid transfer is essential to uncovering the fundamentals of resistance transfer and for the development of predictive measures to limit the spread of resistance. However, a major limitation in the current understanding of plasmids is the incomplete characterization of the conjugative DNA transfer mechanisms, which conceals the actual potential for plasmid transfer in nature. Here, we consider that the plasmid‐borne origin‐of‐transfer substrates encode specific DNA structural properties that can facilitate finding these regions in large datasets and develop a DNA structure‐based alignment procedure for typing the transfer substrates that outperforms sequence‐based approaches. Thousands of putative DNA transfer substrates are identified, showing that plasmid mobility can be twofold higher and span almost twofold more host species than is currently known. Over half of all putative mobile plasmids contain the means for mobilization by conjugation systems belonging to different mobility groups, which can hypothetically link previously confined host ranges across ecological habitats into a robust plasmid transfer network. This hypothetical network is found to facilitate the transfer of antimicrobial resistance from environmental genetic reservoirs to human pathogens, which might be an important driver of the observed rapid resistance development in humans and thus an important point of focus for future prevention measures." @default.
- W3094951569 created "2020-11-09" @default.
- W3094951569 creator A5018788438 @default.
- W3094951569 date "2020-10-27" @default.
- W3094951569 modified "2023-10-18" @default.
- W3094951569 title "Multiple plasmid origin‐of‐transfer regions might aid the spread of antimicrobial resistance to human pathogens" @default.
- W3094951569 cites W1543881158 @default.
- W3094951569 cites W1724214647 @default.
- W3094951569 cites W1829807246 @default.
- W3094951569 cites W1849979647 @default.
- W3094951569 cites W1963692635 @default.
- W3094951569 cites W1963984053 @default.
- W3094951569 cites W1964640602 @default.
- W3094951569 cites W1965022500 @default.
- W3094951569 cites W1970019286 @default.
- W3094951569 cites W1974089947 @default.
- W3094951569 cites W1974231532 @default.
- W3094951569 cites W1976099809 @default.
- W3094951569 cites W1983668396 @default.
- W3094951569 cites W1988580441 @default.
- W3094951569 cites W1989342781 @default.
- W3094951569 cites W1992298603 @default.
- W3094951569 cites W1996852546 @default.
- W3094951569 cites W1998467050 @default.
- W3094951569 cites W1999590523 @default.
- W3094951569 cites W2004960255 @default.
- W3094951569 cites W2007592424 @default.
- W3094951569 cites W2009095852 @default.
- W3094951569 cites W2012015946 @default.
- W3094951569 cites W2012210882 @default.
- W3094951569 cites W2012627860 @default.
- W3094951569 cites W2012719938 @default.
- W3094951569 cites W2023563789 @default.
- W3094951569 cites W2027585195 @default.
- W3094951569 cites W2029136933 @default.
- W3094951569 cites W2029987289 @default.
- W3094951569 cites W2031123552 @default.
- W3094951569 cites W2032007025 @default.
- W3094951569 cites W2032268510 @default.
- W3094951569 cites W2040102858 @default.
- W3094951569 cites W2046917389 @default.
- W3094951569 cites W2053742705 @default.
- W3094951569 cites W2055043387 @default.
- W3094951569 cites W2058952776 @default.
- W3094951569 cites W2067924339 @default.
- W3094951569 cites W2070755960 @default.
- W3094951569 cites W2083201065 @default.
- W3094951569 cites W2084212424 @default.
- W3094951569 cites W2085558835 @default.
- W3094951569 cites W2089234452 @default.
- W3094951569 cites W2093812788 @default.
- W3094951569 cites W2095994064 @default.
- W3094951569 cites W2101536723 @default.
- W3094951569 cites W2104378409 @default.
- W3094951569 cites W2109089063 @default.
- W3094951569 cites W2111400482 @default.
- W3094951569 cites W2112612986 @default.
- W3094951569 cites W2119978464 @default.
- W3094951569 cites W2121438595 @default.
- W3094951569 cites W2121748291 @default.
- W3094951569 cites W2121997159 @default.
- W3094951569 cites W2128769815 @default.
- W3094951569 cites W2133096610 @default.
- W3094951569 cites W2134852597 @default.
- W3094951569 cites W2135995702 @default.
- W3094951569 cites W2138403886 @default.
- W3094951569 cites W2150614077 @default.
- W3094951569 cites W2151029800 @default.
- W3094951569 cites W2151450070 @default.
- W3094951569 cites W2155844132 @default.
- W3094951569 cites W2156843961 @default.
- W3094951569 cites W2160456443 @default.
- W3094951569 cites W2161163382 @default.
- W3094951569 cites W2163480486 @default.
- W3094951569 cites W2164269384 @default.
- W3094951569 cites W2167866277 @default.
- W3094951569 cites W2168867828 @default.
- W3094951569 cites W2169074029 @default.
- W3094951569 cites W2174432380 @default.
- W3094951569 cites W2223719905 @default.
- W3094951569 cites W2227999376 @default.
- W3094951569 cites W2268267797 @default.
- W3094951569 cites W2270106114 @default.
- W3094951569 cites W2339423458 @default.
- W3094951569 cites W2346475297 @default.
- W3094951569 cites W2411481305 @default.
- W3094951569 cites W2520608710 @default.
- W3094951569 cites W2528511189 @default.
- W3094951569 cites W2530537403 @default.
- W3094951569 cites W2543813668 @default.
- W3094951569 cites W2552936918 @default.
- W3094951569 cites W2565998200 @default.
- W3094951569 cites W2588968372 @default.
- W3094951569 cites W2594414408 @default.
- W3094951569 cites W2597258243 @default.
- W3094951569 cites W2604271274 @default.
- W3094951569 cites W2620979206 @default.
- W3094951569 cites W2657744962 @default.
- W3094951569 cites W2756958651 @default.
- W3094951569 cites W2766807003 @default.