Matches in SemOpenAlex for { <https://semopenalex.org/work/W3095034769> ?p ?o ?g. }
- W3095034769 endingPage "5083" @default.
- W3095034769 startingPage "5083" @default.
- W3095034769 abstract "The review presents data from the last few years on bioanalytical methods used in therapeutic drug monitoring (TDM) of the 1st–3rd generation and the newest antiepileptic drug (AEDs) cenobamate in patients with various forms of seizures. Chemical classification, structure, mechanism of action, pharmacokinetic data and therapeutic ranges for total and free fractions and interactions were collected. The primary data on bioanalytical methods for AEDs determination included biological matrices, sample preparation, dried blood spot (DBS) analysis, column resolution, detection method, validation parameters, and clinical utility. In conclusion, the most frequently described method used in AED analysis is the LC-based technique (HPLC, UHPLC, USLC) combined with highly sensitive mass detection or fluorescence detection. However, less sensitive UV is also used. Capillary electrophoresis and gas chromatography have been rarely applied. Besides the precipitation of proteins or LLE, an automatic SPE is often a sample preparation method. Derivatization was also indicated to improve sensitivity and automate the analysis. The usefulness of the methods for TDM was also highlighted." @default.
- W3095034769 created "2020-11-09" @default.
- W3095034769 creator A5008357536 @default.
- W3095034769 creator A5011536859 @default.
- W3095034769 creator A5018321572 @default.
- W3095034769 creator A5040597279 @default.
- W3095034769 date "2020-11-02" @default.
- W3095034769 modified "2023-10-03" @default.
- W3095034769 title "New Methods Used in Pharmacokinetics and Therapeutic Monitoring of the First and Newer Generations of Antiepileptic Drugs (AEDs)" @default.
- W3095034769 cites W1178726026 @default.
- W3095034769 cites W1501480366 @default.
- W3095034769 cites W1530894628 @default.
- W3095034769 cites W1587375887 @default.
- W3095034769 cites W1746862192 @default.
- W3095034769 cites W1762041142 @default.
- W3095034769 cites W1791721089 @default.
- W3095034769 cites W1890048425 @default.
- W3095034769 cites W1891915183 @default.
- W3095034769 cites W1960629422 @default.
- W3095034769 cites W1973808700 @default.
- W3095034769 cites W1975592638 @default.
- W3095034769 cites W1975640256 @default.
- W3095034769 cites W1976777079 @default.
- W3095034769 cites W1978170044 @default.
- W3095034769 cites W1984264616 @default.
- W3095034769 cites W1994019015 @default.
- W3095034769 cites W1995396359 @default.
- W3095034769 cites W2001345449 @default.
- W3095034769 cites W2002195122 @default.
- W3095034769 cites W2003333851 @default.
- W3095034769 cites W2008321445 @default.
- W3095034769 cites W2013489830 @default.
- W3095034769 cites W2015342345 @default.
- W3095034769 cites W2017552339 @default.
- W3095034769 cites W2017887283 @default.
- W3095034769 cites W2020621444 @default.
- W3095034769 cites W2021644238 @default.
- W3095034769 cites W2021722452 @default.
- W3095034769 cites W2022912616 @default.
- W3095034769 cites W2024470143 @default.
- W3095034769 cites W2027386886 @default.
- W3095034769 cites W2033989135 @default.
- W3095034769 cites W2041936193 @default.
- W3095034769 cites W2045172500 @default.
- W3095034769 cites W2056461128 @default.
- W3095034769 cites W2060047735 @default.
- W3095034769 cites W2060587811 @default.
- W3095034769 cites W2060769952 @default.
- W3095034769 cites W2062261408 @default.
- W3095034769 cites W2064414486 @default.
- W3095034769 cites W2065430456 @default.
- W3095034769 cites W2065782446 @default.
- W3095034769 cites W2069987842 @default.
- W3095034769 cites W2071150289 @default.
- W3095034769 cites W2071934663 @default.
- W3095034769 cites W2073245622 @default.
- W3095034769 cites W2074288938 @default.
- W3095034769 cites W2079248878 @default.
- W3095034769 cites W2080467925 @default.
- W3095034769 cites W2083402697 @default.
- W3095034769 cites W2084700873 @default.
- W3095034769 cites W2084981126 @default.
- W3095034769 cites W2085056557 @default.
- W3095034769 cites W2086608015 @default.
- W3095034769 cites W2088117588 @default.
- W3095034769 cites W2088804069 @default.
- W3095034769 cites W2089402359 @default.
- W3095034769 cites W2093080629 @default.
- W3095034769 cites W2094089029 @default.
- W3095034769 cites W2102234164 @default.
- W3095034769 cites W2102644906 @default.
- W3095034769 cites W2111054299 @default.
- W3095034769 cites W2112494412 @default.
- W3095034769 cites W2116080756 @default.
- W3095034769 cites W2117463099 @default.
- W3095034769 cites W2121964016 @default.
- W3095034769 cites W2130967723 @default.
- W3095034769 cites W2131885470 @default.
- W3095034769 cites W2137558027 @default.
- W3095034769 cites W2138502200 @default.
- W3095034769 cites W2153182649 @default.
- W3095034769 cites W2158025851 @default.
- W3095034769 cites W2180374861 @default.
- W3095034769 cites W2197978006 @default.
- W3095034769 cites W2224835203 @default.
- W3095034769 cites W2267930951 @default.
- W3095034769 cites W2305946666 @default.
- W3095034769 cites W2307799019 @default.
- W3095034769 cites W2312961094 @default.
- W3095034769 cites W2315862006 @default.
- W3095034769 cites W2320685137 @default.
- W3095034769 cites W2347009999 @default.
- W3095034769 cites W2405670694 @default.
- W3095034769 cites W2485520811 @default.
- W3095034769 cites W2497848139 @default.
- W3095034769 cites W2515141951 @default.
- W3095034769 cites W2517998519 @default.
- W3095034769 cites W2522515401 @default.